Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Mllt4 - myeloid/lymphoid or mixed-lineage leukemia...

Rattus norvegicus

Synonyms: Af6, Afadin, Protein Af-6

Lee, N.P. et al., Konrad, L. et al., Mandai, K. et al.

Konrad, Munir Keilani, Cordes, Völck-Badouin, Laible, Albrecht, Renneberg, Aumüller,

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High impact information on Af6

These results suggest that l-afadin serves as a linker of the actin cytoskeleton to the plasma membrane at cell-to-cell AJ [1].
These analyses reveal, to our knowledge for the first time, that the testis may indeed be using the cadherin/catenin complex as one of the functional units to regulate AJ dynamics between Sertoli and germ cells in addition to alpha(6)beta(1) integrin and the nectin/afadin complex [2].
Additionally, the immortalized cells express afadin, a protein which is a member of tight and adherens junctions, therefore the cells may be useful for studies of the blood-testis barrier (BTB) in vitro [3].

References

Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. Mandai, K., Nakanishi, H., Satoh, A., Obaishi, H., Wada, M., Nishioka, H., Itoh, M., Mizoguchi, A., Aoki, T., Fujimoto, T., Matsuda, Y., Tsukita, S., Takai, Y. J. Cell Biol. (1997) [Pubmed]
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Lee, N.P., Mruk, D., Lee, W.M., Cheng, C.Y. Biol. Reprod. (2003) [Pubmed]
Rat Sertoli cells express epithelial but also mesenchymal genes after immortalization with SV40. Konrad, L., Munir Keilani, M., Cordes, A., Völck-Badouin, E., Laible, L., Albrecht, M., Renneberg, H., Aumüller, G. Biochim. Biophys. Acta (2005) [Pubmed]

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MLLT4	Bos taurus
afd-1	Caenorhabditis elegans
MLLT4	Canis lupus familiaris
mllt4a	Danio rerio
MLLT4	Gallus gallus
MLLT4	Homo sapiens
MLLT4	Macaca mulatta
Mllt4	Mus musculus
MLLT4	Pan troglodytes
mllt4	Xenopus (Silurana) tropicalis

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