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MeSH Review

Blood-Testis Barrier

 
 
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Disease relevance of Blood-Testis Barrier

 

High impact information on Blood-Testis Barrier

 

Biological context of Blood-Testis Barrier

 

Anatomical context of Blood-Testis Barrier

 

Associations of Blood-Testis Barrier with chemical compounds

 

Gene context of Blood-Testis Barrier

  • We conclude that P-gp is involved in the self-protection of the somatic cells and is most probably one of the molecules that confers its functionality to the blood-testis barrier [24].
  • In mammals the MDR1 (P-glycoprotein) extrudes large hydrophobic compounds and provides the basis of the blood-brain and the blood-testis barrier for such molecules [25].
  • TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study [26].
  • Postnatal day 14 marked the appearance of an intense, focal band-like localization of occludin at the base of the tubules, correlating with the appearance of a functional blood-testis barrier [27].
  • Pituitary adenylate cyclase activating polypeptide (PACAP) can cross the vascular component of the blood-testis barrier in the mouse [28].

References

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  2. The blood-testis barrier in men with varicocele: a lanthanum tracer study. Cameron, D.F., Snydle, F.E. Fertil. Steril. (1980) [Pubmed]
  3. Differential zinc transport into testis and brain of cadmium-sensitive and -resistant murine strains. King, L.M., Banks, W.A., George, W.J. J. Androl. (2000) [Pubmed]
  4. The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse. Mizushima, H., Nakamura, Y., Matsumoto, H., Dohi, K., Matsumoto, K., Shioda, S., Banks, W.A. J. Androl. (2001) [Pubmed]
  5. Erythropoietin expression in primary rat Sertoli and peritubular myoid cells. Magnanti, M., Gandini, O., Giuliani, L., Gazzaniga, P., Marti, H.H., Gradilone, A., Frati, L., Aglianò, A.M., Gassmann, M. Blood (2001) [Pubmed]
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  7. Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men. Ghosn, J., Chaix, M.L., Peytavin, G., Rey, E., Bresson, J.L., Goujard, C., Katlama, C., Viard, J.P., Tréluyer, J.M., Rouzioux, C. AIDS (2004) [Pubmed]
  8. Male infertility due to germ cell apoptosis in mice lacking the thiamin carrier, Tht1. A new insight into the critical role of thiamin in spermatogenesis. Oishi, K., Barchi, M., Au, A.C., Gelb, B.D., Diaz, G.A. Dev. Biol. (2004) [Pubmed]
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  10. A 22-amino acid synthetic peptide corresponding to the second extracellular loop of rat occludin perturbs the blood-testis barrier and disrupts spermatogenesis reversibly in vivo. Chung, N.P., Mruk, D., Mo, M.Y., Lee, W.M., Cheng, C.Y. Biol. Reprod. (2001) [Pubmed]
  11. Effect of cadmium chloride on transepithelial electrical resistance of Sertoli cell monolayers in two-compartment cultures--a new model for toxicological investigations of the "blood-testis" barrier in vitro. Janecki, A., Jakubowiak, A., Steinberger, A. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  12. Rabbit sex hormone-binding globulin: expression in the liver and testis during postnatal development and structural characterization by truncated proteins. Wong, A.S., Lui, W.Y., Hui, I.T., Lee, W.M. Int. J. Androl. (2001) [Pubmed]
  13. Spermatogenesis and blood-testis barrier in rats after long-term Vitamin A deprivation. Morales, A., Cavicchia, J.C. Tissue & cell. (2002) [Pubmed]
  14. Role of basic-helix-loop-helix transcription factors in Sertoli cell differentiation: identification of an E-box response element in the transferrin promoter. Chaudhary, J., Cupp, A.S., Skinner, M.K. Endocrinology (1997) [Pubmed]
  15. Plasminogen activator inhibitor-1 is expressed in cultured rat Sertoli cells. Le Magueresse-Battistoni, B., Pernod, G., Sigillo, F., Kolodié, L., Benahmed, M. Biol. Reprod. (1998) [Pubmed]
  16. Steroid entry into rete testis fluid and the blood-testis barrier. Cooper, T.G., Waites, G.M. J. Endocrinol. (1975) [Pubmed]
  17. The testicular iron shuttle: a "nurse" function of the Sertoli cells. Sylvester, S.R., Griswold, M.D. J. Androl. (1994) [Pubmed]
  18. The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat. Levy, S., Serre, V., Hermo, L., Robaire, B. J. Androl. (1999) [Pubmed]
  19. Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. Hoffer, A.P., Hinton, B.T. Biol. Reprod. (1984) [Pubmed]
  20. Aspects of the testicular toxicity of phthalate esters. Gray, T.J., Gangolli, S.D. Environ. Health Perspect. (1986) [Pubmed]
  21. An evaluation of the integrity of the blood-testis barrier by magnetic resonance imaging. Farghali, H., Williams, D.S., Simplaceanu, E., Ho, C., Van Thiel, D.H. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1991) [Pubmed]
  22. Demonstration of a functional blood-testis barrier to acetaldehyde. Evidence for lack of acetaldehyde effect on ethanol-induced depression of testosterone in vivo. Anderson, R.A., Quigg, J.M., Oswald, C., Zaneveld, L.J. Biochem. Pharmacol. (1985) [Pubmed]
  23. Glycerol disrupts tight junction-associated actin microfilaments, occludin, and microtubules in Sertoli cells. Wiebe, J.P., Kowalik, A., Gallardi, R.L., Egeler, O., Clubb, B.H. J. Androl. (2000) [Pubmed]
  24. Multidrug resistance genes and p-glycoprotein in the testis of the rat, mouse, Guinea pig, and human. Melaine, N., Liénard, M.O., Dorval, I., Le Goascogne, C., Lejeune, H., Jégou, B. Biol. Reprod. (2002) [Pubmed]
  25. The multidrug transporters--proteins of an ancient immune system. Sarkadi, B., Müller, M., Holló, Z. Immunol. Lett. (1996) [Pubmed]
  26. TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study. Lui, W.Y., Wong, C.H., Mruk, D.D., Cheng, C.Y. Endocrinology (2003) [Pubmed]
  27. Cellular immunolocalization of occludin during embryonic and postnatal development of the mouse testis and epididymis. Cyr, D.G., Hermo, L., Egenberger, N., Mertineit, C., Trasler, J.M., Laird, D.W. Endocrinology (1999) [Pubmed]
  28. Pituitary adenylate cyclase activating polypeptide (PACAP) can cross the vascular component of the blood-testis barrier in the mouse. Banks, W.A., Kastin, A.J., Komaki, G., Arimura, A. J. Androl. (1993) [Pubmed]
 
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