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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood-Testis Barrier

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Disease relevance of Blood-Testis Barrier


High impact information on Blood-Testis Barrier


Biological context of Blood-Testis Barrier


Anatomical context of Blood-Testis Barrier


Associations of Blood-Testis Barrier with chemical compounds


Gene context of Blood-Testis Barrier

  • We conclude that P-gp is involved in the self-protection of the somatic cells and is most probably one of the molecules that confers its functionality to the blood-testis barrier [24].
  • In mammals the MDR1 (P-glycoprotein) extrudes large hydrophobic compounds and provides the basis of the blood-brain and the blood-testis barrier for such molecules [25].
  • TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study [26].
  • Postnatal day 14 marked the appearance of an intense, focal band-like localization of occludin at the base of the tubules, correlating with the appearance of a functional blood-testis barrier [27].
  • Pituitary adenylate cyclase activating polypeptide (PACAP) can cross the vascular component of the blood-testis barrier in the mouse [28].


  1. Penetration of the nucleoside analogue abacavir into the genital tract of men infected with human immunodeficiency virus type 1. van Praag, R.M., van Heeswijk, R.P., Jurriaans, S., Lange, J.M., Hoetelmans, R.M., Prins, J.M. Clin. Infect. Dis. (2001) [Pubmed]
  2. The blood-testis barrier in men with varicocele: a lanthanum tracer study. Cameron, D.F., Snydle, F.E. Fertil. Steril. (1980) [Pubmed]
  3. Differential zinc transport into testis and brain of cadmium-sensitive and -resistant murine strains. King, L.M., Banks, W.A., George, W.J. J. Androl. (2000) [Pubmed]
  4. The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse. Mizushima, H., Nakamura, Y., Matsumoto, H., Dohi, K., Matsumoto, K., Shioda, S., Banks, W.A. J. Androl. (2001) [Pubmed]
  5. Erythropoietin expression in primary rat Sertoli and peritubular myoid cells. Magnanti, M., Gandini, O., Giuliani, L., Gazzaniga, P., Marti, H.H., Gradilone, A., Frati, L., Aglianò, A.M., Gassmann, M. Blood (2001) [Pubmed]
  6. Dynamic cross-talk between cells and the extracellular matrix in the testis. Siu, M.K., Cheng, C.Y. Bioessays (2004) [Pubmed]
  7. Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men. Ghosn, J., Chaix, M.L., Peytavin, G., Rey, E., Bresson, J.L., Goujard, C., Katlama, C., Viard, J.P., Tréluyer, J.M., Rouzioux, C. AIDS (2004) [Pubmed]
  8. Male infertility due to germ cell apoptosis in mice lacking the thiamin carrier, Tht1. A new insight into the critical role of thiamin in spermatogenesis. Oishi, K., Barchi, M., Au, A.C., Gelb, B.D., Diaz, G.A. Dev. Biol. (2004) [Pubmed]
  9. The blood-testis barrier in experimental unilateral cryptorchidism. Stewart, R.J., Boyd, S., Brown, S., Toner, P.G. J. Pathol. (1990) [Pubmed]
  10. A 22-amino acid synthetic peptide corresponding to the second extracellular loop of rat occludin perturbs the blood-testis barrier and disrupts spermatogenesis reversibly in vivo. Chung, N.P., Mruk, D., Mo, M.Y., Lee, W.M., Cheng, C.Y. Biol. Reprod. (2001) [Pubmed]
  11. Effect of cadmium chloride on transepithelial electrical resistance of Sertoli cell monolayers in two-compartment cultures--a new model for toxicological investigations of the "blood-testis" barrier in vitro. Janecki, A., Jakubowiak, A., Steinberger, A. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  12. Rabbit sex hormone-binding globulin: expression in the liver and testis during postnatal development and structural characterization by truncated proteins. Wong, A.S., Lui, W.Y., Hui, I.T., Lee, W.M. Int. J. Androl. (2001) [Pubmed]
  13. Spermatogenesis and blood-testis barrier in rats after long-term Vitamin A deprivation. Morales, A., Cavicchia, J.C. Tissue & cell. (2002) [Pubmed]
  14. Role of basic-helix-loop-helix transcription factors in Sertoli cell differentiation: identification of an E-box response element in the transferrin promoter. Chaudhary, J., Cupp, A.S., Skinner, M.K. Endocrinology (1997) [Pubmed]
  15. Plasminogen activator inhibitor-1 is expressed in cultured rat Sertoli cells. Le Magueresse-Battistoni, B., Pernod, G., Sigillo, F., Kolodié, L., Benahmed, M. Biol. Reprod. (1998) [Pubmed]
  16. Steroid entry into rete testis fluid and the blood-testis barrier. Cooper, T.G., Waites, G.M. J. Endocrinol. (1975) [Pubmed]
  17. The testicular iron shuttle: a "nurse" function of the Sertoli cells. Sylvester, S.R., Griswold, M.D. J. Androl. (1994) [Pubmed]
  18. The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat. Levy, S., Serre, V., Hermo, L., Robaire, B. J. Androl. (1999) [Pubmed]
  19. Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. Hoffer, A.P., Hinton, B.T. Biol. Reprod. (1984) [Pubmed]
  20. Aspects of the testicular toxicity of phthalate esters. Gray, T.J., Gangolli, S.D. Environ. Health Perspect. (1986) [Pubmed]
  21. An evaluation of the integrity of the blood-testis barrier by magnetic resonance imaging. Farghali, H., Williams, D.S., Simplaceanu, E., Ho, C., Van Thiel, D.H. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1991) [Pubmed]
  22. Demonstration of a functional blood-testis barrier to acetaldehyde. Evidence for lack of acetaldehyde effect on ethanol-induced depression of testosterone in vivo. Anderson, R.A., Quigg, J.M., Oswald, C., Zaneveld, L.J. Biochem. Pharmacol. (1985) [Pubmed]
  23. Glycerol disrupts tight junction-associated actin microfilaments, occludin, and microtubules in Sertoli cells. Wiebe, J.P., Kowalik, A., Gallardi, R.L., Egeler, O., Clubb, B.H. J. Androl. (2000) [Pubmed]
  24. Multidrug resistance genes and p-glycoprotein in the testis of the rat, mouse, Guinea pig, and human. Melaine, N., Liénard, M.O., Dorval, I., Le Goascogne, C., Lejeune, H., Jégou, B. Biol. Reprod. (2002) [Pubmed]
  25. The multidrug transporters--proteins of an ancient immune system. Sarkadi, B., Müller, M., Holló, Z. Immunol. Lett. (1996) [Pubmed]
  26. TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study. Lui, W.Y., Wong, C.H., Mruk, D.D., Cheng, C.Y. Endocrinology (2003) [Pubmed]
  27. Cellular immunolocalization of occludin during embryonic and postnatal development of the mouse testis and epididymis. Cyr, D.G., Hermo, L., Egenberger, N., Mertineit, C., Trasler, J.M., Laird, D.W. Endocrinology (1999) [Pubmed]
  28. Pituitary adenylate cyclase activating polypeptide (PACAP) can cross the vascular component of the blood-testis barrier in the mouse. Banks, W.A., Kastin, A.J., Komaki, G., Arimura, A. J. Androl. (1993) [Pubmed]
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