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Gene Review:

UL55 - nuclear protein UL55

Human herpesvirus 1

Harty, R.N. et al., Sinclair, M.C. et al., Nash, T.C. et al., Block, T. et al.

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Disease relevance of UL55

Transcriptional and translational analyses of the UL2 gene of equine herpesvirus 1: a homolog of UL55 of herpes simplex virus type 1 that is maintained in the genome of defective interfering particles [1].
DNA sequences at the L terminus, which contain the UL2 gene (homolog of UL55 of herpes simplex virus type 1 and open reading frame 3 of varicella-zoster virus) of standard EHV-1, have been shown to be highly conserved in all clones of the EHV-1 DIP genome [1].
These results demonstrate that the HSV-1 UL55 and UL56 genes are not critical for intraperitoneal virulence or establishment of latent infection [2].

High impact information on UL55

Sequence analysis revealed that the deletion removes a region to the right of IE2 comprising the 3' end of IE1, UL56 and the 3' part of UL55, stopping 555 bp downstream of the IE2 polyadenylation signal [3].
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes [4].

References

Transcriptional and translational analyses of the UL2 gene of equine herpesvirus 1: a homolog of UL55 of herpes simplex virus type 1 that is maintained in the genome of defective interfering particles. Harty, R.N., Holden, V.R., O'Callaghan, D.J. J. Virol. (1993) [Pubmed]
The UL55 and UL56 genes of herpes simplex virus type 1 are not required for viral replication, intraperitoneal virulence, or establishment of latency in mice. Nash, T.C., Spivack, J.G. Virology (1994) [Pubmed]
Characterization of a herpes simplex virus type 1 deletion variant (1703) which under-produces Vmw63 during immediate early conditions of infection. Sinclair, M.C., McLauchlan, J., Marsden, H., Brown, S.M. J. Gen. Virol. (1994) [Pubmed]
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes. Block, T., Jordan, R., Farkas, D.H., Hughes, R.G. J. Gen. Virol. (1991) [Pubmed]

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