Disease relevance of LYPD3

• As demonstrated for malignant melanoma, C4.4A mRNA expression correlated with tumor progression [1].
• While nevi were negative and only a minority of primary malignant melanoma expressed C4.4A, all metastases were C4.4A-positive [1].
• Phorbol-ester-induced hyperplasia of mouse skin is also accompanied by a significant induction of C4.4A expression in the multilayered, suprabasal keratinocytes [2].

High impact information on LYPD3

• One confirmed but unknown differentially expressed sequence was used to isolate a full-length gene, MIG-C4, from a human urothelial cDNA library [3].
• By in situ hybridization, MIG-C4 was expressed variably in normal urothelium and intensely in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers [3].
• Upregulation of C4.4A expression during progression of melanoma [4].
• Expression of the human C4.4A was observed by RT-PCR and Northern blotting in placental tissue, skin, esophagus and peripheral blood leukocytes, but not in brain, lung, liver, kidney, stomach, colon and lymphoid organs [1].
• By immunohistochemistry we observed a pronounced surface staining for C4.4A in suprabasal keratinocytes of chronic human wounds and found C4.4A expression markedly upregulated in migrating keratinocytes during re-epithelisation of incisional skin wounds [2].

Anatomical context of LYPD3

• The natural, glycolipid-anchored C4.4A from amnion membranes of human term placenta exhibits similar properties [2].

References