Disease relevance of F1010_11

• Transformation of Escherichia coli to sulfonamide resistance was associated with the acquisition of a 4.9-megadalton plasmid, which did not confer linked resistance to streptomycin [1].
• Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi [1].
• This type of sulfonamide resistance is very frequently found among gram-negative bacteria because of its efficient spread to various plasmids [2].

High impact information on F1010_11

• RSF1010 and a conjugative plasmid contain sulII, one of two known genes for plasmid-borne sulfonamide resistance dihydropteroate synthase [2].
• The nucleotide sequence of the type II sulfonamide resistance dihydropteroate synthase (sulII) gene was determined [2].
• The sequence organizations in the Sm Su plasmids RSF1010 and pBP1 were shown to be identical for regions specifying streptomycin and sulfonamide resistance, but different for the region containing the origin of replication and genes for replicative functions [3].
• In addition, most members of the commonest family of integrons (class 1) include a sulfonamide resistance determinant in the backbone structure [4].
• A correlation with type of sulfonamide resistance gene in Escherichia coli and synergy between trimethoprim and sulfamethoxazole [5].

Chemical compound and disease context of F1010_11

• Molecular nature of a streptomycin and sulfonamide resistance plasmid (pBP1) prevalent in clinical Escherichia coli strains and integration of an ampicillin resistance transposon (TnA) [3].

References