The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

dihydropterate     4-[(2-amino-4-oxo-7,8- dihydro-1H-pteridin...

Synonyms: H2Pte, SureCN609952, CHEBI:4581, AG-E-56424, SureCN1332736, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dihydropteroic acid


High impact information on Dihydropteroic acid


Chemical compound and disease context of Dihydropteroic acid


Biological context of Dihydropteroic acid


Anatomical context of Dihydropteroic acid


Associations of Dihydropteroic acid with other chemical compounds


Gene context of Dihydropteroic acid


Analytical, diagnostic and therapeutic context of Dihydropteroic acid


  1. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study. Navin, T.R., Beard, C.B., Huang, L., del Rio, C., Lee, S., Pieniazek, N.J., Carter, J.L., Le, T., Hightower, A., Rimland, D. Lancet (2001) [Pubmed]
  2. Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy. Mathieu, M., Debousker, G., Vincent, S., Viviani, F., Bamas-Jacques, N., Mikol, V. J. Biol. Chem. (2005) [Pubmed]
  3. Structure-activity of sulfones and sulfonamides on dihydropteroate synthetase from Neisseria meingitidis. Ho, R.I., Corman, L., Mores, S.A., Schneider, H. Antimicrob. Agents Chemother. (1975) [Pubmed]
  4. Sequence variations in the genes encoding dihydropteroate synthase and dihydrofolate reductase and clinical response to sulfadoxine-pyrimethamine in patients with acute uncomplicated falciparum malaria. Basco, L.K., Tahar, R., Keundjian, A., Ringwald, P. J. Infect. Dis. (2000) [Pubmed]
  5. New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors. Suling, W.J., Seitz, L.E., Reynolds, R.C., Barrow, W.W. Antimicrob. Agents Chemother. (2005) [Pubmed]
  6. Failure of co-trimoxazole in Pneumocystis carinii infection and mutations in dihydropteroate synthase gene. Mei, Q., Gurunathan, S., Masur, H., Kovacs, J.A. Lancet (1998) [Pubmed]
  7. Folate biosynthesis in higher plants: purification and molecular cloning of a bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase localized in mitochondria. Rébeillé, F., Macherel, D., Mouillon, J.M., Garin, J., Douce, R. EMBO J. (1997) [Pubmed]
  8. Identifying two ancient enzymes in Archaea using predicted secondary structure alignment. Xu, H., Aurora, R., Rose, G.D., White, R.H. Nat. Struct. Biol. (1999) [Pubmed]
  9. Cloning and characterization of a DNA fragment that confers sulfonamide resistance in a serogroup B, serotype 15 strain of Neisseria meningitidis. Kristiansen, B.E., Rådström, P., Jenkins, A., Ask, E., Facinelli, B., Sköld, O. Antimicrob. Agents Chemother. (1990) [Pubmed]
  10. Pyrimethamine/sulfadoxine combination in the treatment of uncomplicated falciparum malaria: relation between dihydropteroate synthase/dihydrofolate reductase genotypes, sulfadoxine plasma levels, and treatment outcome. Khalil, I., Alifrangis, M., Rønn, A.M., Gabar, H.A., Jelinek, T., Satti, G.M., Bygbjerg, I.C. Am. J. Trop. Med. Hyg. (2002) [Pubmed]
  11. Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding. Sheng, Y., Cross, J.A., Shen, Y., Smith, C.A., Bognar, A.L. Arch. Biochem. Biophys. (2002) [Pubmed]
  12. Identification of dihydropteroate (DHPS) gene mutant in Pneumocystis carinii in respiratory samples of HIV+ patients from 1992 to 1997. Visconti, E., Ortona, E., Margutti, P., Marinaci, S., Zolfo, M., Mencarini, P., Celentano, L.P., Siracusano, A., Tamburrini, E. J. Eukaryot. Microbiol. (1999) [Pubmed]
  13. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Watanabe, H., Hastings, J.W. Biochim. Biophys. Acta (1990) [Pubmed]
  14. Pneumocystis jirovecii dihydropteroate synthase genotypes in immunocompetent infants and immunosuppressed adults, Amiens, France. Totet, A., Latouche, S., Lacube, P., Pautard, J.C., Jounieaux, V., Raccurt, C., Roux, P., Nevez, G. Emerging Infect. Dis. (2004) [Pubmed]
  15. Multiresistance plasmid from commensal Neisseria strains. Pintado, C., Salvador, C., Rotger, R., Nombela, C. Antimicrob. Agents Chemother. (1985) [Pubmed]
  16. Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase. Swedberg, G., Ringertz, S., Sköld, O. Antimicrob. Agents Chemother. (1998) [Pubmed]
  17. Quantitative structure-activity relationship studies of a series of sulfa drugs as inhibitors of Pneumocystis carinii dihydropteroate synthetase. Johnson, T., Khan, I.A., Avery, M.A., Grant, J., Meshnick, S.R. Antimicrob. Agents Chemother. (1998) [Pubmed]
  18. RSF1010 and a conjugative plasmid contain sulII, one of two known genes for plasmid-borne sulfonamide resistance dihydropteroate synthase. Rådström, P., Swedberg, G. Antimicrob. Agents Chemother. (1988) [Pubmed]
  19. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. Plowe, C.V., Cortese, J.F., Djimde, A., Nwanyanwu, O.C., Watkins, W.M., Winstanley, P.A., Estrada-Franco, J.G., Mollinedo, R.E., Avila, J.C., Cespedes, J.L., Carter, D., Doumbo, O.K. J. Infect. Dis. (1997) [Pubmed]
  20. Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients. Nahimana, A., Rabodonirina, M., Zanetti, G., Meneau, I., Francioli, P., Bille, J., Hauser, P.M. J. Infect. Dis. (2003) [Pubmed]
  21. Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy. Takahashi, T., Hosoya, N., Endo, T., Nakamura, T., Sakashita, H., Kimura, K., Ohnishi, K., Nakamura, Y., Iwamoto, A. J. Clin. Microbiol. (2000) [Pubmed]
  22. The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase. Volpe, F., Dyer, M., Scaife, J.G., Darby, G., Stammers, D.K., Delves, C.J. Gene (1992) [Pubmed]
  23. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Brooks, D.R., Wang, P., Read, M., Watkins, W.M., Sims, P.F., Hyde, J.E. Eur. J. Biochem. (1994) [Pubmed]
  24. Site-directed mutagenesis of the Saccharomyces cerevisiae dihydropteroate synthase FOL1 gene to study Pneumocystis jirovecii mutations in the orthologue gene FAS. Meneau, I., Sanglard, D., Bille, J., Hauser, P.M. J. Eukaryot. Microbiol. (2003) [Pubmed]
  25. Resistance to trimethoprim and sulfonamides. Sköld, O. Vet. Res. (2001) [Pubmed]
  26. Transformation of Penicillium chrysogenum to sulfonamide resistance. Carramolino, L., Lozano, M., Pérez-Aranda, A., Rubio, V., Sánchez, F. Gene (1989) [Pubmed]
  27. Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus. Kellam, P., Dallas, W.S., Ballantine, S.P., Delves, C.J. FEMS Microbiol. Lett. (1995) [Pubmed]
  28. Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction--food for thought? Aspinall, T.V., Marlee, D., Hyde, J.E., Sims, P.F. Int. J. Parasitol. (2002) [Pubmed]
  29. Molecular epidemiology of malaria in Yaounde, Cameroon II. Baseline frequency of point mutations in the dihydropteroate synthase gene of Plasmodium falciparum. Basco, L.K., Ringwald, P. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
  30. A simple and rapid thin-layer chromatography method to follow the kinetics of product formation by 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase and 7,8-dihydropteroate synthetase. Bock, L., Butte, W., Richter, M., Seydel, J.K. Anal. Biochem. (1978) [Pubmed]
  31. Dihydropteroate synthase: purification by affinity chromatography and mechanism of action. Suckling, C.J., Sweeney, J.R., Wood, H.C. J. Chem. Soc. Perkin Trans. I (1977) [Pubmed]
  32. Engineering dihydropteroate synthase (DHPS) for efficient expression on M13 phage. Brockmann, E.C., Lamminmäki, U., Saviranta, P. Biochim. Biophys. Acta (2005) [Pubmed]
WikiGenes - Universities