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Gene Review

Clnk  -  cytokine-dependent hematopoietic cell linker

Mus musculus

Synonyms: Cytokine-dependent hematopoietic cell linker, MIST, Mast cell immunoreceptor signal transducer, Mist
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High impact information on Clnk

  • Moreover, transient expression of Clnk caused an increase in immunoreceptor-mediated signaling events in a T cell line [1].
  • We have identified a novel Src homology 2 domain-containing leukocyte protein of 76 kD (SLP-76)-related molecule which we have termed Clnk (for cytokine-dependent hemopoietic cell linker) [1].
  • Moreover, ectopic expression of Clnk was shown to rescue T-cell receptor-mediated signal transduction in an SLP-76-deficient T-cell line, suggesting that, like its relatives, Clnk is involved in the positive regulation of immunoreceptor signaling [2].
  • The results of our studies demonstrated that Clnk is dispensable for normal differentiation and function of T cells, mast cells, and NK cells [2].
  • Stimulatory effects of Clnk on immunoreceptor signaling were also reported to occur in transfected B-cell and basophil leukemia cell lines [2].

Biological context of Clnk

  • Overexpression of a mutant form of MIST/Clnk inhibited FcepsilonRI-mediated degranulation, increase in intracellular Ca(2+), NF-AT activation and phosphorylation of LAT [3].

Anatomical context of Clnk


Other interactions of Clnk

  • Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells [2].


  1. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. Cao, M.Y., Davidson, D., Yu, J., Latour, S., Veillette, A. J. Exp. Med. (1999) [Pubmed]
  2. Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Utting, O., Sedgmen, B.J., Watts, T.H., Shi, X., Rottapel, R., Iulianella, A., Lohnes, D., Veillette, A. Mol. Cell. Biol. (2004) [Pubmed]
  3. A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. Goitsuka, R., Kanazashi, H., Sasanuma, H., Fujimura, Y., Hidaka, Y., Tatsuno, A., Ra, C., Hayashi, K., Kitamura, D. Int. Immunol. (2000) [Pubmed]
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