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Gene Review

GOLIM4  -  golgi integral membrane protein 4

Homo sapiens

Synonyms: GIMPC, GIMPc, GOLPH4, GPP130, Golgi integral membrane protein 4, ...
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High impact information on GOLPH4

  • Furthermore, two proteins whose Golgi targeting depends on endosome-to-Golgi retrieval in the bypass pathway accumulated in early/recycling endosomes in the absence of GPP130 [1].
  • An RNA interference-based test revealed that GPP130 was required for efficient exit of Shiga toxin B-fragment from endosomes en route to the Golgi apparatus [1].
  • The use of lumenal determinants for both basolateral cycling and endosome-to-Golgi retrieval suggests that a novel receptor-mediated mechanism operates at both the trans-Golgi network and distal sites to sort GPP130 along the late-endosome-bypass retrieval pathway in polarized cells [2].
  • Golgi phosphoprotein of 130 kDa (GPP130) is a cis-Golgi protein that allows assay of retrieval-based targeting because it redistributes to endosomes upon treatment with agents that disrupt lumenal pH, and it undergoes endosome-to-Golgi retrieval upon drug removal [3].
  • Because monensin blocks endosome-to-Golgi transport, the finding that the endosomal determinant confers monensin sensitivity suggests that the endosomal determinant causes GPP130 to traffic to endosomes from which it is normally retrieved [3].

Anatomical context of GOLPH4

  • Analysis of chimeric molecules containing domains from GPP130 and the plasma membrane protein dipeptidylpeptidase IV indicated that GPP130 targeting information is contained entirely within its lumenal domain [3].
  • In vivo recordings were made from the somatosensory cortex from postnatal day (P) 55 to P138, in response to electrical stimulation of the infraorbital nerve supplying the mystacial whiskers [4].

Associations of GOLPH4 with chemical compounds

  • In contrast to the behavior of previously studied type II Golgi proteins, overexpression of GPP130 led to a pronounced accumulation in endocytotic vesicles, and endogenous GPP130 reversibly redistributed to endocytotic vesicles after chloroquine treatment [5].
  • Unlike the TGN marker TGN38/46, GPP130 and GP73 colocalized in the early Golgi and redistributed to the ER after brefeldin A treatment [6].

Other interactions of GOLPH4

  • Although GP73 did not associate with GPP130, its steady-state Golgi targeting was also mediated by a lumenal predicted coiled-coil stem domain [6].


  1. A cycling cis-Golgi protein mediates endosome-to-Golgi traffic. Natarajan, R., Linstedt, A.D. Mol. Biol. Cell (2004) [Pubmed]
  2. Basolateral cycling mediated by a lumenal domain targeting determinant. Puthenveedu, M.A., Bruns, J.R., Weisz, O.A., Linstedt, A.D. Mol. Biol. Cell (2003) [Pubmed]
  3. Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein. Bachert, C., Lee, T.H., Linstedt, A.D. Mol. Biol. Cell (2001) [Pubmed]
  4. Developmental onset of functional activity in the wallaby whisker cortex in response to stimulation of the infraorbital nerve. Mark, R.F., Flett, D.L., Marotte, L.R., Waite, P.M. Somatosensory & motor research. (2002) [Pubmed]
  5. Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. Linstedt, A.D., Mehta, A., Suhan, J., Reggio, H., Hauri, H.P. Mol. Biol. Cell (1997) [Pubmed]
  6. Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption. Puri, S., Bachert, C., Fimmel, C.J., Linstedt, A.D. Traffic (2002) [Pubmed]
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