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Gene Review

ACBD3  -  acyl-CoA binding domain containing 3

Homo sapiens

Synonyms: Acyl-CoA-binding domain-containing protein 3, GCP60, GOCAP1, GOLPH1, Golgi complex-associated protein 1, ...
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Disease relevance of ACBD3

  • These studies showed that, like in the mouse, human PAP7 is highly expressed in steroidogenic tissues, where it follows the pattern of PRKAR1A expression, suggesting that it participates in PRKAR1A-mediated tumorigenesis and hypercortisolism [1].

High impact information on ACBD3


Biological context of ACBD3

  • Overexpression of the COOH-terminal domain of GCP60 caused disassembly of the Golgi structure and blocked protein transport from the endoplasmic reticulum to the Golgi [6].
  • Treatment of MA-10 cells with oligonucleotides antisense to PAP7 also inhibited the hCG-stimulated steroid formation, suggesting that PAP7 is a functional element of the hormone-induced signal transduction cascade leading to steroidogenesis [7].
  • The full-length mouse PAP7 gene was cloned and assembled by screening a BAC clone, polymerase chain reaction and searching the mouse genome database [8].
  • Although it is shorter than the human PAP7 gene, all exons are conserved between the mouse and human [8].
  • The mouse PAP7 gene was mapped to chromosome 1H3-5 by fluorescence in situ hybridization in agreement with in silico search of the mouse genome database that mapped the PAP7 cDNA sequence to the 1H4 area [8].

Anatomical context of ACBD3


Associations of ACBD3 with chemical compounds

  • Overexpression of the full length PAP7 increased the hCG-induced steroid production [7].
  • The predicted protein, GCP364 (for a Golgi complex-associated protein of 364 kDa), was found to have no NH2-terminal signal sequence but a single hydrophobic domain at the COOH terminus and characteristically contain many coiled-coil domains with various sizes throughout the entire sequence [9].

Physical interactions of ACBD3


Other interactions of ACBD3

  • PAP7 and PRKAR1A expression were studied in PPNAD and in lymphoblasts from patients bearing PRKAR1A-mut [1].
  • Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin [6].
  • Golgi phosphoprotein of 130 kDa (GPP130) is a cis-Golgi protein that allows assay of retrieval-based targeting because it redistributes to endosomes upon treatment with agents that disrupt lumenal pH, and it undergoes endosome-to-Golgi retrieval upon drug removal [10].
  • This strong interaction prevented the golgin-160 fragment from accumulating in the nucleus when this fragment and GCP60 were overexpressed [5].


  1. Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues. Liu, J., Matyakhina, L., Han, Z., Sandrini, F., Bei, T., Stratakis, C.A., Papadopoulos, V. FASEB J. (2003) [Pubmed]
  2. NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Cheah, J.H., Kim, S.F., Hester, L.D., Clancy, K.W., Patterson, S.E., Papadopoulos, V., Snyder, S.H. Neuron (2006) [Pubmed]
  3. Exit of major histocompatibility complex class II-invariant chain p35 complexes from the endoplasmic reticulum is modulated by phosphorylation. Kuwana, T., Peterson, P.A., Karlsson, L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. Liu, J., Rone, M.B., Papadopoulos, V. J. Biol. Chem. (2006) [Pubmed]
  5. GCP60 Preferentially Interacts with a Caspase-generated Golgin-160 Fragment. Sbodio, J.I., Hicks, S.W., Simon, D., Machamer, C.E. J. Biol. Chem. (2006) [Pubmed]
  6. Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin. Sohda, M., Misumi, Y., Yamamoto, A., Yano, A., Nakamura, N., Ikehara, Y. J. Biol. Chem. (2001) [Pubmed]
  7. Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. Li, H., Degenhardt, B., Tobin, D., Yao, Z.X., Tasken, K., Papadopoulos, V. Mol. Endocrinol. (2001) [Pubmed]
  8. Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein. Liu, J., Cavalli, L.R., Haddad, B.R., Papadopoulos, V. Gene (2003) [Pubmed]
  9. Identification and characterization of rat 364-kDa Golgi-associated protein recognized by autoantibodies from a patient with rheumatoid arthritis. Toki, C., Fujiwara, T., Sohda, M., Hong, H.S., Misumi, Y., Ikehara, Y. Cell Struct. Funct. (1997) [Pubmed]
  10. Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein. Bachert, C., Lee, T.H., Linstedt, A.D. Mol. Biol. Cell (2001) [Pubmed]
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