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Gene Review

ind  -  intermediate neuroblasts defective

Drosophila melanogaster

Synonyms: CG11551, Dmel\CG11551, Ind, ind/Gsx
 
 
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High impact information on ind

 

Biological context of ind

  • Understanding the mechanisms involved in patterning vnd, ind, and msh expression is important, because DV columnar homeobox gene expression in the neuroectoderm is an early, essential, and evolutionarily conserved step in generating neuronal diversity along the DV axis of the CNS [3].
  • For example, the misexpression of vnd in transgenic embryos represses ind and msh, and the addition of Vnd binding sites to a heterologous enhancer is sufficient to mediate repression [4].
  • In this and the accompanying paper, we investigate the role of two homeobox genes, vnd and ind, in establishing ventral and intermediate cell fates within the Drosophila CNS [5].
  • The ind enhancer also contains a variety of known activator and repressor elements [6].
  • A novel silencer element was identified within the ind enhancer that is essential for eliminating expression in the dorsal ectoderm [6].
 

Regulatory relationships of ind

  • Ectopic expression of sim in the ventral neuroectoderm during initial neurogenesis induced ectopic ind expression in the medial column in addition to that in the intermediate column via EGFR signaling between the ventral neuroectoderm and midline cells [7].
 

Other interactions of ind

  • However, we uncovered significant differences in the expression of and regulatory interactions between vnd, ind and msh among brain segments, and in comparison to the ventral nerve cord [8].
  • Genetic interactions of SoxNeuro and the dorsoventral patterning genes ventral nerve chord defective and intermediate neuroblasts defective underlie ventral and intermediate neuroblast formation [9].

References

  1. Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Weiss, J.B., Von Ohlen, T., Mellerick, D.M., Dressler, G., Doe, C.Q., Scott, M.P. Genes Dev. (1998) [Pubmed]
  2. The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm. Zhao, G., Skeath, J.B. Development (2002) [Pubmed]
  3. Convergence of dorsal, dpp, and egfr signaling pathways subdivides the drosophila neuroectoderm into three dorsal-ventral columns. von Ohlen, T., Doe, C.Q. Dev. Biol. (2000) [Pubmed]
  4. Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo. Cowden, J., Levine, M. Dev. Biol. (2003) [Pubmed]
  5. Dorsoventral patterning in the Drosophila central nervous system: the vnd homeobox gene specifies ventral column identity. McDonald, J.A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C.Q., Mellerick, D.M. Genes Dev. (1998) [Pubmed]
  6. Localized repressors delineate the neurogenic ectoderm in the early Drosophila embryo. Stathopoulos, A., Levine, M. Dev. Biol. (2005) [Pubmed]
  7. CNS midline cells contribute to maintenance of the initial dorsoventral patterning of the Drosophila ventral neuroectoderm. Kim, I.O., Kim, I.C., Kim, S., Kwon, Y.K., Han, P.L., Jeon, S.H., Kim, S.H. J. Neurobiol. (2005) [Pubmed]
  8. Segment-specific requirements for dorsoventral patterning genes during early brain development in Drosophila. Urbach, R., Volland, D., Seibert, J., Technau, G.M. Development (2006) [Pubmed]
  9. Formation of neuroblasts in the embryonic central nervous system of Drosophila melanogaster is controlled by SoxNeuro. Buescher, M., Hing, F.S., Chia, W. Development (2002) [Pubmed]
 
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