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Gene Review

MLN  -  motilin

Bos taurus

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High impact information on MLN

  • Comparison of all known sequences shows considerable identity in amino acid and nucleotide sequence of the signal peptide and motilin [1].
  • Motilin cDNA fragments were amplified by PCR, ligated into a plasmid and cloned [1].
  • The importance of enteric neural influence from the duodenum and the role of motilin in the regulation of pancreatic periodicity and its synchronization with the duodenal motility cycle remain to be determined [2].
  • Feeding was followed by a transitory reduction of plasma somatostatin and by a prolonged decrease of plasma motilin [3].
  • In addition, motilin-immunoreactive cells were identified in both the endocrine and exocrine pancreas of pouch-young and adult echidnas using three types of motilin antisera [4].

Anatomical context of MLN

  • A survey of endocrine cells in the pancreas of the echidna (Tachyglossus aculeatus) with special reference to pancreatic motilin cells [4].

Other interactions of MLN

  • Moderate numbers of 5-HT-immunoreactive cells, small to moderate numbers of neurotensin- and enteroglucagon-immunoreactive cells and occasional somatostatin-, motilin- and BPP-immunoreactive cells were seen in the distal intestine [5].


  1. Sequence and characterization of cDNA encoding the motilin precursor from chicken, dog, cow and horse. Evidence of mosaic evolution in prepromotilin. Huang, Z., Depoortere, I., De Clercq, P., Peeters, T. Gene (1999) [Pubmed]
  2. Effect of neural blockades, gastrointestinal regulatory peptides, and diversion of gastroduodenal contents on periodic pancreatic secretion in the preruminant calf. Zabielski, R., Kiela, P., Onaga, T., Mineo, H., Gregory, P.C., Kato, S. Can. J. Physiol. Pharmacol. (1995) [Pubmed]
  3. Early-life patterns of plasma gut regulatory peptide levels in calves: effects of the first meals. Guilloteau, P., Chayvialle, J.A., Toullec, R., Grongnet, J.F., Bernard, C. Biol. Neonate (1992) [Pubmed]
  4. A survey of endocrine cells in the pancreas of the echidna (Tachyglossus aculeatus) with special reference to pancreatic motilin cells. Yamada, J., Krause, W.J., Edwin, N., Mochizuki, T., Yanaihara, N. J. Anat. (1990) [Pubmed]
  5. An immunohistochemical study of the endocrine cells in the gastrointestinal mucosa of the Caiman latirostris. Yamada, J., Campos, V.J., Kitamura, N., Pacheco, A.C., Yamashita, T., Yanaihara, N. Archivum histologicum Japonicum. Nippon soshikigaku kiroku. (1987) [Pubmed]
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