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Gene Review

MLN  -  motilin

Canis lupus familiaris

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Disease relevance of MLN


Psychiatry related information on MLN


High impact information on MLN


Chemical compound and disease context of MLN


Biological context of MLN


Anatomical context of MLN


Associations of MLN with chemical compounds


Regulatory relationships of MLN


Other interactions of MLN

  • RESULTS: A single injection of EM523 always induced phase III-like contractions in the intact gastric antrum and was accompanied by significant (P < 0.01) release of motilin, pancreatic polypeptide, and insulin; glucagon, gastrin, cholecystokinin, and secretin were not released by EM523 [26].
  • In addition, serum levels of motilin and PYY were determined before and during the administration of 1500 cGy in four separate dogs instrumented to record upper gut contractile activity [27].
  • No immunoreactive neurons were observed with the available antisera to galanin, gastrin-releasing peptide, and motilin [28].

Analytical, diagnostic and therapeutic context of MLN

  • Porcine and canine motilin in plasma were distinguished by radioimmunoassay using two different antibodies [10].
  • Effect of central sympathectomy on gastric and small intestinal myoelectric activity and plasma motilin concentrations in the dog [29].
  • Pancreatectomy led to undetectable plasma concentrations of pancreatic polypeptide, but had no effect on absolute concentrations of plasma motilin or on the cycling of plasma motilin in association with the duodenal migrating motor complex [30].
  • Intravenous infusion of PG (4 micrograms/kg-hr) inhibited motilin-induced phase III activity both in the main stomach and in the HP, whereas histamine (40 micrograms/kg-hr) inhibited activity only in the main stomach [31].
  • Before and after vagotomy, motilin and insulin induced a premature MMC with minor changes in contractile pattern [32].


  1. Effect of 13-NLE-motilin on gastric secretion, serum gastrin level and mucosal blood flow in dogs. Konturek, S.J., Dembinski, A., Krol, R., Wünsch, E. J. Physiol. (Lond.) (1977) [Pubmed]
  2. The role of motilin in periodic interdigestive pancreatic secretion in dogs. Magee, D.F., Naruse, S. J. Physiol. (Lond.) (1984) [Pubmed]
  3. An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs. Inatomi, N., Satoh, H., Maki, Y., Hashimoto, N., Itoh, Z., Omura, S. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  4. Gastrointestinal peptide hormones during postoperative ileus. Effect of octreotide. Cullen, J.J., Eagon, J.C., Kelly, K.A. Dig. Dis. Sci. (1994) [Pubmed]
  5. Effect of motilin on pancreatic secretion. Konturek, S.J., Król, R., Dembiński, A., Wünsch, E. Pflugers Arch. (1976) [Pubmed]
  6. Relationships among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma pancreatic polypeptide, and motilin. Keane, F.B., DiMagno, E.P., Dozois, R.R., Go, V.L. Gastroenterology (1980) [Pubmed]
  7. Effect of cisplatin on myoelectric activity of the stomach and small intestine in dogs. Chey, R.D., Lee, K.Y., Asbury, R., Chey, W.Y. Dig. Dis. Sci. (1988) [Pubmed]
  8. Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog. Aizawa, I., Itoh, Z., Harris, V., Unger, R.H. J. Clin. Invest. (1981) [Pubmed]
  9. Motilin regulates interdigestive gastric blood flow in dogs. Jin, C., Naruse, S., Kitagawa, M., Ishiguro, H., Muxin, W., Nakajima, M., Yokohata, K., Ito, O., Hayakawa, T. Gastroenterology (2002) [Pubmed]
  10. Relationship between porcine motilin-induced migrating motor complex-like activity, vagal integrity, and endogenous motilin release in dogs. Hall, K.E., Greenberg, G.R., El-Sharkawy, T.Y., Diamant, N.E. Gastroenterology (1984) [Pubmed]
  11. Motilin-induced electrical activity in the canine gastrointestinal tract. Wingate, D.L., Ruppin, H., Green, W.E., Thompson, H.H., Domschke, W., Wünsch, E., Demling, L., Ritchie, H.D. Scand. J. Gastroenterol. Suppl. (1976) [Pubmed]
  12. Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs. Narita, T., Okabe, N., Hane, M., Yamamoto, Y., Tani, K., Naito, Y., Hara, S. J. Vet. Pharmacol. Ther. (2006) [Pubmed]
  13. The vagus, motilin, and the migrating motor complex. Diamant, N.E., Chung, S.A., Hall, K.E. Gastroenterology (1994) [Pubmed]
  14. Effects of corticotropin-releasing factor on plasma motilin and somatostatin levels and gastrointestinal motility in dogs. Bueno, L., Fargeas, M.J., Gue, M., Peeters, T.L., Bormans, V., Fioramonti, J. Gastroenterology (1986) [Pubmed]
  15. Motilin enhances gastric emptying of liquids in dogs. Debas, H.T., Yamagishi, T., Dryburgh, J.R. Gastroenterology (1977) [Pubmed]
  16. Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs. Shiba, Y., Mizumoto, A., Inatomi, N., Haga, N., Yamamoto, O., Itoh, Z. Gastroenterology (1995) [Pubmed]
  17. Structure-activity relationships of gastrointestinal hormones: motilin, GIP, and [27-TYR]CCK-PZ. Yajima, H., Kai, Y., Ogawa, H., Kubota, M., Mori, Y. Gastroenterology (1977) [Pubmed]
  18. Role of the duodenum in the control of canine gastrointestinal motility. Tanaka, M., Sarr, M.G. Gastroenterology (1988) [Pubmed]
  19. Differential sensitivities of morphine and motilin to initiate migrating motor complex in isolated intestinal segments. Regeneration of intrinsic nerves. Matsumoto, T., Sarna, S.K., Condon, R.E., Cowles, V.E., Frantzides, C. Gastroenterology (1986) [Pubmed]
  20. Comparison of gallbladder contractions induced by motilin and cholecystokinin in dogs. Takahashi, I., Suzuki, T., Aizawa, I., Itoh, Z. Gastroenterology (1982) [Pubmed]
  21. Mechanism of motilin-induced contractions in isolated perfused canine stomach. Mizumoto, A., Sano, I., Matsunaga, Y., Yamamoto, O., Itoh, Z., Ohshima, K. Gastroenterology (1993) [Pubmed]
  22. Comparative stimulation of motilin duodenal receptor by porcine or canine motilin. Poitras, P., Lahaie, R.G., St-Pierre, S., Trudel, L. Gastroenterology (1987) [Pubmed]
  23. Involvement of 5-hydroxytryptamine 3 receptors in regulation of interdigestive gastric contractions by motilin in the dog. Itoh, Z., Mizumoto, A., Iwanaga, Y., Yoshida, N., Torii, K., Wakabayashi, K. Gastroenterology (1991) [Pubmed]
  24. Mechanism of gastroprokinetic effect of EM523, an erythromycin derivative, in dogs. Ohtawa, M., Mizumoto, A., Hayashi, N., Yanagida, K., Itoh, Z., Omura, S. Gastroenterology (1993) [Pubmed]
  25. Modulation of motilin-induced somatostatin release in dogs by naloxone. Schick, R., Schusdziarra, V. Peptides (1985) [Pubmed]
  26. Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs. Shiba, Y., Mizumoto, A., Satoh, M., Inui, A., Itoh, Z., Omura, S. Gastroenterology (1996) [Pubmed]
  27. Fractionated irradiation alters enteric neuroendocrine products. Otterson, M.F., Koch, T.R., Zhang, Z., Leming, S.C., Moulder, J.E. Dig. Dis. Sci. (1995) [Pubmed]
  28. Canine jejunal submucosa cultures: characterization and release of neural somatostatin. Buchan, A.M., Doyle, A.D., Accili, E. Can. J. Physiol. Pharmacol. (1990) [Pubmed]
  29. Effect of central sympathectomy on gastric and small intestinal myoelectric activity and plasma motilin concentrations in the dog. Telford, G.L., Go, V.L., Szurszewski, J.H. Gastroenterology (1985) [Pubmed]
  30. Role of the pancreas in the control of interdigestive gastrointestinal motility. Malfertheiner, P., Sarr, M.G., DiMagno, E.P. Gastroenterology (1989) [Pubmed]
  31. Inhibition of motilin-induced phase III contractions by pentagastrin in Heidenhain pouch dogs. Yamamoto, O., Matsunaga, Y., Shiba, Y., Haga, N., Sano, I., Itoh, Z. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  32. Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex. Tanaka, T., Kendrick, M.L., Zyromski, N.J., Meile, T., Sarr, M.G. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
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