Disease relevance of CHAD

• This slaughterhouse study in Chad shows higher proportions of Mycobacterium bovis isolates among Mbororo than Arabe zebu cattle [1].
• Rift Valley fever virus infection among French troops in Chad [2].

High impact information on CHAD

• The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage [3].
• A leucine-rich protein, chondroadherin, has been isolated from dissociative extracts of articular cartilage, and its primary structure has been determined by both direct protein sequencing and DNA sequence analysis of polymerase chain reaction products and cDNA clones [3].
• Chondroadherin, which is reported to be synthesized by chondrocytes and to promote their attachment, was purified from bovine bone [4].
• Binding of chondroadherin to collagen was significantly higher than that of osteonectin or decorin [4].
• Epidemiology of Trypanosoma vivax infection in cattle in the tse-tse free area of Lake Chad [5].

Biological context of CHAD

• VNTR typing of the five highly discriminative loci (h=0.917) proved to be most appropriate for first line typing of M. bovis strains of Chad and superior than spoligotyping (h(sp)=0.789) [6].

References