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Gene Review

CHAD  -  chondroadherin

Bos taurus

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Disease relevance of CHAD

  • This slaughterhouse study in Chad shows higher proportions of Mycobacterium bovis isolates among Mbororo than Arabe zebu cattle [1].
  • Rift Valley fever virus infection among French troops in Chad [2].

High impact information on CHAD


Biological context of CHAD

  • VNTR typing of the five highly discriminative loci (h=0.917) proved to be most appropriate for first line typing of M. bovis strains of Chad and superior than spoligotyping (h(sp)=0.789) [6].


  1. Mycobacterium bovis isolates from tuberculous lesions in Chadian zebu carcasses. Diguimbaye-Djaibé, C., Hilty, M., Ngandolo, R., Mahamat, H.H., Pfyffer, G.E., Baggi, F., Hewinson, G., Tanner, M., Zinsstag, J., Schelling, E. Emerging Infect. Dis. (2006) [Pubmed]
  2. Rift Valley fever virus infection among French troops in Chad. Durand, J.P., Bouloy, M., Richecoeur, L., Peyrefitte, C.N., Tolou, H. Emerging Infect. Dis. (2003) [Pubmed]
  3. The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage. Neame, P.J., Sommarin, Y., Boynton, R.E., Heinegård, D. J. Biol. Chem. (1994) [Pubmed]
  4. Bone chondroadherin promotes attachment of osteoblastic cells to solid-state substrates and shows affinity to collagen. Mizuno, M., Fujisawa, R., Kuboki, Y. Calcif. Tissue Int. (1996) [Pubmed]
  5. Epidemiology of Trypanosoma vivax infection in cattle in the tse-tse free area of Lake Chad. Delafosse, A., Thébaud, E., Desquesnes, M., Michaux, Y. Prev. Vet. Med. (2006) [Pubmed]
  6. Evaluation of the discriminatory power of variable number tandem repeat (VNTR) typing of Mycobacterium bovis strains. Hilty, M., Diguimbaye, C., Schelling, E., Baggi, F., Tanner, M., Zinsstag, J. Vet. Microbiol. (2005) [Pubmed]
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