Gene Review:
Chad - chondroadherin
Rattus norvegicus
Synonyms:
Cartilage leucine-rich protein, Chondroadherin
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Disease relevance of Chad
- For design of oligonucleotide probes and primers a 1664 bp, full length, rat chondroadherin cDNA was isolated from a rat chondrosarcoma library and sequenced [1].
High impact information on Chad
- With increasing age a very distinct localization of chondroadherin was seen in the territorial matrix around late proliferative cells in the growth plate as well as in the developing articular cartilage in the maturing femoral head [1].
- The high expression of this cell binding protein in a dynamic region of cartilage suggests an important role for chondroadherin in the regulation of chondrocyte growth and proliferation [1].
- Northern blot analysis showed chondroadherin mRNA to be present in femoral head and rib cartilage, as well as in tendon [1].
Analytical, diagnostic and therapeutic context of Chad
- Localization of chondroadherin by immunocytochemistry in the developing femoral head from postnatal day 14 to day 60 showed presence of the protein in cartilaginous regions [1].
- A three-fold increase of cartilage chondroadherin content in the growing femoral head was demonstrated by Western blot analysis [1].
References
- Chondroadherin expression changes in skeletal development. Shen, Z., Gantcheva, S., Mânsson, B., Heinegârd, D., Sommarin, Y. Biochem. J. (1998) [Pubmed]
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