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Gene Review

Chad  -  chondroadherin

Mus musculus

Synonyms: Cartilage leucine-rich protein, Chondroadherin, SLRR4A
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High impact information on Chad


Biological context of Chad


Anatomical context of Chad


Analytical, diagnostic and therapeutic context of Chad

  • Southern blot analysis of mouse genomic DNA revealed a simple pattern of hybridization indicating a single copy gene for chondroadherin [2].
  • RESULTS: RT-PCR analysis showed strong expression of Chad in mouse brain, heart, lung, and embryo [4].
  • Using mouse serotyping, the currently accepted method for the identification of spotted fever group rickettsiae, the Chad isolate exhibited a specificity difference of 2 when compared to Astrakhan fever rickettsia and at least 4 when compared with other members of the R. conorii complex [5].


  1. A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Yu, Y.E., Morishima, M., Pao, A., Wang, D.Y., Wen, X.Y., Baldini, A., Bradley, A. Genetics (2006) [Pubmed]
  2. The mouse chondroadherin gene: characterization and chromosomal localization. Landgren, C., Beier, D.R., Fässler, R., Heinegård, D., Sommarin, Y. Genomics (1998) [Pubmed]
  3. Serological relationships and epitope profiles of isolates of okra leaf curl geminivirus from Africa and the Middle East. Swanson, M.M., Harrison, B.D. Biochimie (1993) [Pubmed]
  4. Analysis of the expression of chondroadherin in mouse ocular and non-ocular tissues. Tasheva, E.S., Ke, A., Conrad, G.W. Mol. Vis. (2004) [Pubmed]
  5. Isolation of a rickettsia related to Astrakhan fever rickettsia from a patient in Chad. Fournier, P.E., Xeridat, B., Raoult, D. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
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