High impact information on LOC407111

• Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis [1].
• We examined the mechanism of the protective effect of IGF-I against Fas ligand-induced apoptosis of granulosa cells and its relationship to cell proliferation [2].
• Granulosa cells isolated 0, 6, and 10 h after GnRH were sensitive to Fas ligand-induced apoptosis, but cells isolated at 14 h were resistant [3].
• Fas ligand (FasL) is implicated as a mediator of luteolysis [4].
• Detection of Fas ligand in the bovine oviduct [5].

Biological context of LOC407111

• Functionally, Fas ligand-induced inhibition of endothelium-dependent vasorelaxation was reduced if LRs were disrupted or NADPH oxidase was inhibited [6].
• Experiments were conducted to test whether oestradiol (E2) protects granulosa cells from Fas ligand (FasL)-induced apoptosis and whether protection involves modulation of the cell cycle of proliferation [7].

Anatomical context of LOC407111

• Our previous studies have shown that bovine granulosa cells cultured in basal media supplemented with 5% fetal bovine serum (BM-FBS) are resistant to apoptosis induced by recombinant Fas ligand (FasL) unless pretreated with interferon-gamma (IFN) [8].
• By confocal microscopic analysis of agonist-stimulated rafts patch formation, we found that several death receptor ligands or apoptotic factors, including tumor necrosis factor alpha, Fas ligand, or endostatin, stimulated the clustering and trafficking of individual LRs on the plasma membrane of coronary endothelial cells [6].
• Apoptosis of bovine ovarian surface epithelial cells by Fas antigen/Fas ligand signaling [9].
• Besides their helper function to other cells of the immune system, activated CD4+ T-lymphocytes might also exert cytotoxic activity, induce apoptosis in target cells via Fas/Fas ligand binding and thus contribute to the severity of tissue lesions in MD [10].

Associations of LOC407111 with chemical compounds

• Granulosa cells isolated before the LH surge were susceptible to apoptosis induced by soluble Fas ligand or serum withdrawal, while cells isolated after the LH surge were resistant to apoptosis [11].
• Treatment of granulosa cells isolated from small antral follicles with the G1 phase blocker, mimosine, reduced Fas ligand-induced killing, suggesting that nonproliferating cells are resistant to apoptosis [3].

Physical interactions of LOC407111

• Fas antigen is a receptor that triggers apoptosis when bound by Fas ligand (FasL) [12].

Regulatory relationships of LOC407111

• Interestingly, double labeling of a membrane-bound NADPH oxidase subunit, gp91phox, and LRs showed that gp91phox colocalized within the LR patches when endothelial cells were stimulated by Fas ligand [6].

Analytical, diagnostic and therapeutic context of LOC407111

• The bovine Fas ligand gene was partially cloned and mRNA expression determined by RT-PCR in a panel of T cell clones [13].

References