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Gene Review

FASLG  -  Fas ligand (TNF superfamily, member 6)

Bos taurus

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High impact information on LOC407111


Biological context of LOC407111


Anatomical context of LOC407111

  • Our previous studies have shown that bovine granulosa cells cultured in basal media supplemented with 5% fetal bovine serum (BM-FBS) are resistant to apoptosis induced by recombinant Fas ligand (FasL) unless pretreated with interferon-gamma (IFN) [8].
  • By confocal microscopic analysis of agonist-stimulated rafts patch formation, we found that several death receptor ligands or apoptotic factors, including tumor necrosis factor alpha, Fas ligand, or endostatin, stimulated the clustering and trafficking of individual LRs on the plasma membrane of coronary endothelial cells [6].
  • Apoptosis of bovine ovarian surface epithelial cells by Fas antigen/Fas ligand signaling [9].
  • Besides their helper function to other cells of the immune system, activated CD4+ T-lymphocytes might also exert cytotoxic activity, induce apoptosis in target cells via Fas/Fas ligand binding and thus contribute to the severity of tissue lesions in MD [10].

Associations of LOC407111 with chemical compounds


Physical interactions of LOC407111


Regulatory relationships of LOC407111


Analytical, diagnostic and therapeutic context of LOC407111


  1. Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis. Küenzi, P., Schneider, P., Dobbelaere, D.A. J. Immunol. (2003) [Pubmed]
  2. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor I-mediated suppression of apoptosis in granulosa cells. Hu, C.L., Cowan, R.G., Harman, R.M., Quirk, S.M. Mol. Endocrinol. (2004) [Pubmed]
  3. Progesterone receptor and the cell cycle modulate apoptosis in granulosa cells. Quirk, S.M., Cowan, R.G., Harman, R.M. Endocrinology (2004) [Pubmed]
  4. Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38(MAPK). Pru, J.K., Hendry, I.R., Davis, J.S., Rueda, B.R. Endocrinology (2002) [Pubmed]
  5. Detection of Fas ligand in the bovine oviduct. Bergqvist, A.S., Killian, G., Erikson, D., Hoshino, Y., Båge, R., Sato, E., Rodríguez-Martínez, H. Anim. Reprod. Sci. (2005) [Pubmed]
  6. Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Zhang, A.Y., Yi, F., Zhang, G., Gulbins, E., Li, P.L. Hypertension (2006) [Pubmed]
  7. The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle. Quirk, S.M., Cowan, R.G., Harman, R.M. J. Endocrinol. (2006) [Pubmed]
  8. Regulation of Fas antigen (Fas, CD95)-mediated apoptosis of bovine granulosa cells by serum and growth factors. Quirk, S.M., Harman, R.M., Cowan, R.G. Biol. Reprod. (2000) [Pubmed]
  9. Apoptosis of bovine ovarian surface epithelial cells by Fas antigen/Fas ligand signaling. Margalit, K.A., Cowan, R.G., Harman, R.M., Quirk, S.M. Reproduction (2005) [Pubmed]
  10. Changes in distribution and numbers of CD4+ and CD8+ T-lymphocytes in lymphoid tissues and intestinal mucosa in the early phase of experimentally induced early onset mucosal disease in cattle. Frink, S., Grummer, B., Pohlenz, J.F., Liebler-Tenorio, E.M. J. Vet. Med. B Infect. Dis. Vet. Public Health (2002) [Pubmed]
  11. Susceptibility of ovarian granulosa cells to apoptosis differs in cells isolated before or after the preovulatory LH surge. Porter, D.A., Harman, R.M., Cowan, R.G., Quirk, S.M. Mol. Cell. Endocrinol. (2001) [Pubmed]
  12. Expression and function of Fas antigen vary in bovine granulosa and theca cells during ovarian follicular development and atresia. Porter, D.A., Vickers, S.L., Cowan, R.G., Huber, S.C., Quirk, S.M. Biol. Reprod. (2000) [Pubmed]
  13. Kinetics of expression and subset distribution of the TNF superfamily members CD40 ligand and Fas ligand on T lymphocytes in cattle. Hirano, A., Brown, W.C., Trigona, W., Tuo, W., Estes, D.M. Vet. Immunol. Immunopathol. (1998) [Pubmed]
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