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Gene Review

FAS  -  Fas cell surface death receptor

Bos taurus

Synonyms: APO1, TNFRSF6
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Disease relevance of TNFRSF6


High impact information on TNFRSF6

  • Fas antigen (Fas Ag; CD95) is a cell surface molecule that can mediate apoptosis [3].
  • Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis [4].
  • We observed upregulation of Fas in beta-cells of type 2 diabetic patients relative to nondiabetic control subjects [5].
  • These results support a new role for glucose in regulating Fas expression in human beta-cells [5].
  • These findings support the concept that CD4(+) CTL lyse macrophages pulsed with BHV-1 polypeptides through a Fas-mediated lytic pathway by inducing apoptosis in the target cells [6].

Biological context of TNFRSF6


Anatomical context of TNFRSF6


Associations of TNFRSF6 with chemical compounds

  • However, a gap exists in our understanding of the Fas-mediated signaling mechanisms that are involved in either the loss of progesterone production or the structural regression of the corpus luteum [12].
  • Fas antigen mRNA was detectable in cultured granulosa and theca cells, and expression was increased by treatment with IFN but not TNF [9].
  • Theca cells were sensitive to Fas-mediated apoptosis before and after exposure to the LH surge [13].
  • These clustered LRs contained high NADPH oxidase activity, which increased in response to Fas stimulation [14].
  • Treatment with anisomycin or daunorubicin in the presence of ZVAD increased expression of FasL mRNA and protein but did not alter expression of Fas mRNA or protein [15].

Physical interactions of TNFRSF6


Regulatory relationships of TNFRSF6

  • IFN increased expression of Fas similarly in all types of media but was required for FasL-induced killing only in BM containing FBS or IGF [11].

Other interactions of TNFRSF6


Analytical, diagnostic and therapeutic context of TNFRSF6


  1. A possible role of Fas antigen in ejaculated spermatozoa of fertile bulls: an immunocytochemical quantitative approach. Meggiolaro, D., Porcelli, F., Carnevali, A., Crepaldi, P., Savarese, E., Ferrandi, B. Acta Histochem. (2006) [Pubmed]
  2. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses. Wang, G.H., Bertin, J., Wang, Y., Martin, D.A., Wang, J., Tomaselli, K.J., Armstrong, R.C., Cohen, J.I. J. Virol. (1997) [Pubmed]
  3. In vitro expansion of hematopoietic progenitor cells induces functional expression of Fas antigen (CD95). Takenaka, K., Nagafuji, K., Harada, M., Mizuno, S., Miyamoto, T., Makino, S., Gondo, H., Okamura, T., Niho, Y. Blood (1996) [Pubmed]
  4. Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis. Küenzi, P., Schneider, P., Dobbelaere, D.A. J. Immunol. (2003) [Pubmed]
  5. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Maedler, K., Spinas, G.A., Lehmann, R., Sergeev, P., Weber, M., Fontana, A., Kaiser, N., Donath, M.Y. Diabetes (2001) [Pubmed]
  6. CD4(+) cytotoxic T-lymphocyte activity against macrophages pulsed with bovine herpesvirus 1 polypeptides. Wang, C., Splitter, G.A. J. Virol. (1998) [Pubmed]
  7. Role of Fas-mediated apoptosis and follicle-stimulating hormone on the developmental capacity of bovine cumulus oocyte complexes in vitro. Rubio Pomar, F.J., Roelen, B.A., Slot, K.A., van Tol, H.T., Colenbrander, B., Teerds, K.J. Biol. Reprod. (2004) [Pubmed]
  8. Cloning and characterization of the bovine Fas. Yoo, J., Stone, R.T., Beattie, C.W. DNA Cell Biol. (1996) [Pubmed]
  9. Expression and activity of the Fas antigen in bovine ovarian follicle cells. Vickers, S.L., Cowan, R.G., Harman, R.M., Porter, D.A., Quirk, S.M. Biol. Reprod. (2000) [Pubmed]
  10. Expression and function of Fas antigen vary in bovine granulosa and theca cells during ovarian follicular development and atresia. Porter, D.A., Vickers, S.L., Cowan, R.G., Huber, S.C., Quirk, S.M. Biol. Reprod. (2000) [Pubmed]
  11. Regulation of Fas antigen (Fas, CD95)-mediated apoptosis of bovine granulosa cells by serum and growth factors. Quirk, S.M., Harman, R.M., Cowan, R.G. Biol. Reprod. (2000) [Pubmed]
  12. Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38(MAPK). Pru, J.K., Hendry, I.R., Davis, J.S., Rueda, B.R. Endocrinology (2002) [Pubmed]
  13. Susceptibility of ovarian granulosa cells to apoptosis differs in cells isolated before or after the preovulatory LH surge. Porter, D.A., Harman, R.M., Cowan, R.G., Quirk, S.M. Mol. Cell. Endocrinol. (2001) [Pubmed]
  14. Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Zhang, A.Y., Yi, F., Zhang, G., Gulbins, E., Li, P.L. Hypertension (2006) [Pubmed]
  15. Apoptosis of bovine ovarian surface epithelial cells by Fas antigen/Fas ligand signaling. Margalit, K.A., Cowan, R.G., Harman, R.M., Quirk, S.M. Reproduction (2005) [Pubmed]
  16. Increased oxidant-induced apoptosis in cultured nondividing human retinal pigment epithelial cells. Jiang, S., Moriarty, S.E., Grossniklaus, H., Nelson, K.C., Jones, D.P., Sternberg, P. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  17. Regulated and endothelial cell-specific expression of Fas ligand: an in vitro model for a strategy aiming at inhibiting xenograft rejection. Tran, T.H., Grey, S., Anrather, J., Steinhäuslin, F., Bach, F.H., Winkler, H. Transplantation (1998) [Pubmed]
  18. Increase in DNA fragmentation and apoptosis-related gene expression in frozen-thawed bovine blastocysts. Park, S.Y., Kim, E.Y., Cui, X.S., Tae, J.C., Lee, W.D., Kim, N.H., Park, S.P., Lim, J.H. Zygote (2006) [Pubmed]
  19. Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism. Chen, X.M., Gores, G.J., Paya, C.V., LaRusso, N.F. Am. J. Physiol. (1999) [Pubmed]
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