The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GUK1  -  guanylate kinase 1

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GUK1

  • Expression of the GK cDNA in E. coli, and the purification and functional characterization of the expressed enzyme are presented [1].

High impact information on GUK1


Biological context of GUK1


Anatomical context of GUK1


Associations of GUK1 with chemical compounds

  • It is shown that bovine retinal GK, like its yeast counterpart, contains the characteristic glycine-rich motif and all the amino acids involved in GMP binding [1].
  • Enzymes of the cyclic GMP metabolism in bovine retina. I. Cloning and expression of the gene for guanylate kinase [1].
  • The presence of three soluble nucleotide phosphotransferases in bovine rod outer segments was demonstrated: guanylate kinase (EC, nucleoside-diphosphate kinase (EC and adenylate kinase (EC [5].
  • Pyrimidine nucleoside monophosphate kinase is not very much affected by such modifications, whereas GMP kinase does not tolerate such alteration [6].


  1. Enzymes of the cyclic GMP metabolism in bovine retina. I. Cloning and expression of the gene for guanylate kinase. Gaidarov, I.O., Suslov, O.N., Abdulaev, N.G. FEBS Lett. (1993) [Pubmed]
  2. Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. Horiguchi, K., Hanada, T., Fukui, Y., Chishti, A.H. J. Cell Biol. (2006) [Pubmed]
  3. Design, synthesis, and structure-activity relationship of novel dinucleotide analogs as agents against herpes and human immunodeficiency viruses. Hakimelahi, G.H., Moosavi-Movahedi, A.A., Sadeghi, M.M., Tsay, S.C., Hwu, J.R. J. Med. Chem. (1995) [Pubmed]
  4. Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. Kim, C.U., Luh, B.Y., Misco, P.F., Bronson, J.J., Hitchcock, M.J., Ghazzouli, I., Martin, J.C. J. Med. Chem. (1990) [Pubmed]
  5. Purification and properties of guanylate kinase from bovine retinas and rod outer segments. Hall, S.W., Kühn, H. Eur. J. Biochem. (1986) [Pubmed]
  6. Synthesis of sugar-modified nucleoside 5'-triphosphates with partially purified nucleotide kinases from calf thymus. Imazawa, M., Eckstein, F. Biochim. Biophys. Acta (1979) [Pubmed]
WikiGenes - Universities