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Gene Review:

PSIP1 - PC4 and SFRS1 interacting protein 1

Bos taurus

Cherepanov, P., Matsui, H. et al., Ayaki, M. et al.

Cherepanov,

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Disease relevance of PSIP1

These results confirm that the interaction with LEDGF is conserved within and limited to Lentivirus and strongly argue that the host factor is intimately involved in the catalysis of lentiviral DNA integration [1].
In contrast, all lentiviral INs examined, including those from bovine immunodeficiency virus (BIV), maedi-visna virus (MVV) and equine infectious anemia virus (EIAV) readily interacted with LEDGF [1].
Transcriptional co-activator LEDGF/p75 is the major cellular interactor of HIV-1 integrase (IN), critical to efficient viral replication [1].

High impact information on PSIP1

CONCLUSIONS: LEDGF enhanced survival of RPE cells in culture when challenged by oxidative stress and UVB irradiation [2].
LEDGF protected RPE cells against H(2)O(2) exposure and UVB irradiation [2].
DNA damage induced by H(2)O(2) exposure or UVB irradiation was lower in the presence than in the absence of LEDGF [2].
Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture [3].

Analytical, diagnostic and therapeutic context of PSIP1

None of the non-lentiviral INs possessed detectable affinity for LEDGF in either pull-down or yeast two-hybrid assays [1].

References

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. Cherepanov, P. Nucleic Acids Res. (2007) [Pubmed]
Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Matsui, H., Lin, L.R., Singh, D.P., Shinohara, T., Reddy, V.N. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture. Ayaki, M., Sueno, T., Singh, D.P., Chylack, L.T., Shinohara, T. Exp. Eye Res. (1999) [Pubmed]

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