Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ARPP19 - cAMP-regulated phosphoprotein, 19kDa

Bos taurus

Synonyms: ARPP-16, ARPP-19

Desdouits, F. et al., Williams, K.R. et al., Desdouits, F. et al., Kurihara, T. et al., Strålfors, P. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ARPP-19

DARPP-32, a dopamine- and cAMP-regulated phosphoprotein of apparent M(r) 32,000, is phosphorylated in vitro by casein kinase I, casein kinase II, and cAMP-dependent protein kinase on sites phosphorylated in vivo [1].
Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin [1].
ARPP-21 (cAMP-regulated phosphoprotein, Mr = 21,000 as determined by SDS-PAGE) is a major cytosolic substrate for cAMP-stimulated protein phosphorylation in dopamine-innervated regions of the rat CNS [2].
A cDNA clone for the mRNA of bovine ARPP-21 (cAMP-regulated phosphoprotein, Mr = 21,000 as determined by SDS-PAGE) was isolated from a modified Okayama-Berg plasmid library [3].
DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, M(r) = 32,000) is a potent inhibitor of protein phosphatase-1 when it is phosphorylated on Thr-34 by cAMP-dependent protein kinase [4].

Anatomical context of ARPP-19

ARPP-16 (cAMP-regulated phosphoprotein of Mr = 16,000) is a substrate for cAMP-dependent protein kinase and is enriched in the basal ganglia [5].
Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical [6].

References

Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin. Desdouits, F., Siciliano, J.C., Greengard, P., Girault, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus. Williams, K.R., Hemmings, H.C., LoPresti, M.B., Greengard, P. J. Neurosci. (1989) [Pubmed]
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Molecular cloning and nucleotide sequence. Kurihara, T., Ehrlich, M.E., Horiuchi, J., Nasu, T., Greengard, P. J. Neurosci. (1989) [Pubmed]
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase I in vitro and in vivo. Desdouits, F., Cohen, D., Nairn, A.C., Greengard, P., Girault, J.A. J. Biol. Chem. (1995) [Pubmed]
Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. Horiuchi, A., Williams, K.R., Kurihara, T., Nairn, A.C., Greengard, P. J. Biol. Chem. (1990) [Pubmed]
Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical. Strålfors, P., Hemmings, H.C., Greengard, P. Eur. J. Biochem. (1989) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ARPP19	Canis lupus familiaris
arpp19a	Danio rerio
ARPP19	Gallus gallus
ARPP19	Homo sapiens
ARPP19	Macaca mulatta
Arpp19	Mus musculus
ARPP19	Pan troglodytes
Arpp19	Rattus norvegicus
arpp19	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.