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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Arpp19  -  cAMP-regulated phosphoprotein 19

Rattus norvegicus

Synonyms: ARPP-19
 
 
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High impact information on Arpp19

  • Overexpression of wild-type ARPP-19 in PC12 cells increased the NGF-dependent expression of a reporter construct linked to the critical 3' region of GAP-43 mRNA [1].
  • Mutation of serine 104, the site of phosphorylation by protein kinase A in ARPP-19, to either alanine or aspartate abolished this regulation in PC12 cells [1].
  • Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19 [1].
  • These findings demonstrate that ARPP-19 is an important link between NGF signaling and post-transcriptional control of neuronal gene expression [1].
  • ARPP-16 and ARPP-19 are 2 cAMP-regulated phosphoproteins of Mr = 16,000 and 19,000, respectively, which are identical except for the presence of 15 additional amino acids on the NH2-terminus of ARPP-19 [2].
 

Biological context of Arpp19

  • ARPP-19 is highly homologous to alpha-endosulfine and database searches allowed the identification of novel related proteins in D. melanogaster, C. elegans, S. mansoni and yeast genomes [3].
 

Anatomical context of Arpp19

  • ARPP-19 was also present at high levels in malignant cell lines [2].
 

Associations of Arpp19 with chemical compounds

  • ARPP-16 is enriched in dopamine-responsive medium spiny neurons in the striatum, while ARPP-19 is ubiquitously expressed [3].

References

  1. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Irwin, N., Chao, S., Goritchenko, L., Horiuchi, A., Greengard, P., Nairn, A.C., Benowitz, L.I. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions. Girault, J.A., Horiuchi, A., Gustafson, E.L., Rosen, N.L., Greengard, P. J. Neurosci. (1990) [Pubmed]
  3. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova, I., Horiuchi, A., Snyder, G.L., Girault, J.A., Czernik, A.J., Shao, L., Ramabhadran, R., Greengard, P., Nairn, A.C. J. Neurochem. (2001) [Pubmed]
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