The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PPP1R1B  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: DARPP-32, DARPP32, Dopamine-and cAMP-regulated neuronal phosphoprotein, FLJ20940, Protein phosphatase 1 regulatory subunit 1B
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PPP1R1B

  • The most frequently overexpressed gene, DARPP32, exhibited strong protein overexpression in 45% (30/66) of the cases in immunohistochemical study of gastric cancer tumor tissue array [1].
  • The purpose of this study was to clarify the roles of DARPP-32 and t-DARPP in oesophageal squamous cell carcinoma (OSCC) [2].
  • Moreover, the observation that DARPP-32 and t-DARPP frequently are overexpressed in common subtypes of human adenocarcinomas suggest that these proteins may be important in tumorigenesis [3].
  • The extent of DARPP-32 and t-DARPP expression in human epithelial tissues and carcinomas remained unknown [3].
  • Monoclonal antibodies were used to demonstrate DARPP-32-like immunoreactivity (LI) in chief cells of the normal human parathyroid gland and in cells of human parathyroid adenoma [4].

High impact information on PPP1R1B


Chemical compound and disease context of PPP1R1B


Biological context of PPP1R1B


Anatomical context of PPP1R1B


Associations of PPP1R1B with chemical compounds


Enzymatic interactions of PPP1R1B


Regulatory relationships of PPP1R1B

  • The present results suggest that DARPP-32 may play a role in the cellular mechanisms leading to dopamine-induced PTH secretion [4].
  • ATP-induced currents were also regulated by phosphatases and cyclin-dependent protein kinase 5 (CDK5) via dopamine and cyclic AMP-regulated phosphoprotein (DARPP-32), though the phosphorylation at Thr-34 and Thr-75 were unchanged or rather attenuated [18].

Other interactions of PPP1R1B

  • ARPP-21 and DARPP-32 mRNA, on the other hand, were present in lower levels in neocortical regions [15].
  • However, the expression levels were independent, showing overexpression of DARPP32 (48%), TOP2A (17%) and ERBB2 (3%) studied by quantitative real-time PCR [1].
  • These data show a transcriptionally active oncogenomic region bounded by PPP1R1B/DARPP-32 and GRB7 in UGCs and provide further insight into expression levels of several critical genes [19].
  • Taken together, the presence of DA and a functional DA receptor and DARPP-32 indicate that a novel, physiological regulatory pathway involving DA exists in the human ovary [16].
  • Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland [4].

Analytical, diagnostic and therapeutic context of PPP1R1B


  1. Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. Varis, A., Zaika, A., Puolakkainen, P., Nagy, B., Madrigal, I., Kokkola, A., Väyrynen, A., Kärkkäinen, P., Moskaluk, C., El-Rifai, W., Knuutila, S. Int. J. Cancer (2004) [Pubmed]
  2. DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma. Ebihara, Y., Miyamoto, M., Fukunaga, A., Kato, K., Shichinohe, T., Kawarada, Y., Kurokawa, T., Cho, Y., Murakami, S., Uehara, H., Kaneko, H., Hashimoto, H., Murakami, Y., Itoh, T., Okushiba, S., Kondo, S., Katoh, H. Br. J. Cancer (2004) [Pubmed]
  3. Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. Beckler, A., Moskaluk, C.A., Zaika, A., Hampton, G.M., Powell, S.M., Frierson, H.F., El-Rifai, W. Cancer (2003) [Pubmed]
  4. Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. Meister, B., Askergren, J., Tunevall, G., Hemmings, H.C., Greengard, P. J. Endocrinol. Invest. (1991) [Pubmed]
  5. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Bibb, J.A., Snyder, G.L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A.A., Tsai, L.H., Kwon, Y.T., Girault, J.A., Czernik, A.J., Huganir, R.L., Hemmings, H.C., Nairn, A.C., Greengard, P. Nature (1999) [Pubmed]
  6. Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Halpain, S., Girault, J.A., Greengard, P. Nature (1990) [Pubmed]
  7. DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Hemmings, H.C., Greengard, P., Tung, H.Y., Cohen, P. Nature (1984) [Pubmed]
  8. DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia. Håkansson, K., Lindskog, M., Pozzi, L., Usiello, A., Fisone, G. Parkinsonism Relat. Disord. (2004) [Pubmed]
  9. Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1. Hansen, C., Greengard, P., Nairn, A.C., Andersson, T., Vogel, W.F. Exp. Cell Res. (2006) [Pubmed]
  10. Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. El-Rifai, W., Smith, M.F., Li, G., Beckler, A., Carl, V.S., Montgomery, E., Knuutila, S., Moskaluk, C.A., Frierson, H.F., Powell, S.M. Cancer Res. (2002) [Pubmed]
  11. D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin. Mayerhofer, A., Fritz, S., Grünert, R., Sanders, S.L., Duffy, D.M., Ojeda, S.R., Stouffer, R.L. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  12. Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. Meister, B., Schultzberg, M., Hemmings, H.C., Greengard, P., Goldstein, M., Hökfelt, T. J. Auton. Nerv. Syst. (1991) [Pubmed]
  13. Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. Endo, S., Suzuki, M., Sumi, M., Nairn, A.C., Morita, R., Yamakawa, K., Greengard, P., Ito, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  14. Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. Kwon, Y.G., Huang, H.B., Desdouits, F., Girault, J.A., Greengard, P., Nairn, A.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  15. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. Brené, S., Lindefors, N., Ehrlich, M., Taubes, T., Horiuchi, A., Kopp, J., Hall, H., Sedvall, G., Greengard, P., Persson, H. J. Neurosci. (1994) [Pubmed]
  16. Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. Mayerhofer, A., Hemmings, H.C., Snyder, G.L., Greengard, P., Boddien, S., Berg, U., Brucker, C. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  17. DARPP-32: an integrator of neurotransmission. Svenningsson, P., Nishi, A., Fisone, G., Girault, J.A., Nairn, A.C., Greengard, P. Annu. Rev. Pharmacol. Toxicol. (2004) [Pubmed]
  18. Parkin potentiates ATP-induced currents due to activation of P2X receptors in PC12 cells. Sato, A., Arimura, Y., Manago, Y., Nishikawa, K., Aoki, K., Wada, E., Suzuki, Y., Osaka, H., Setsuie, R., Sakurai, M., Amano, T., Aoki, S., Wada, K., Noda, M. J. Cell. Physiol. (2006) [Pubmed]
  19. Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas. Maqani, N., Belkhiri, A., Moskaluk, C., Knuutila, S., Dar, A.A., El-Rifai, W. Mol. Cancer Res. (2006) [Pubmed]
  20. Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain. Donohue, T., Hoffman, P.L., Tabakoff, B. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  21. Dopaminergic control of synaptic plasticity in the dorsal striatum. Centonze, D., Picconi, B., Gubellini, P., Bernardi, G., Calabresi, P. Eur. J. Neurosci. (2001) [Pubmed]
WikiGenes - Universities