Gene Review:
PPP1R1B - protein phosphatase 1, regulatory...
Homo sapiens
Synonyms:
DARPP-32, DARPP32, Dopamine-and cAMP-regulated neuronal phosphoprotein, FLJ20940, Protein phosphatase 1 regulatory subunit 1B
- Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. Varis, A., Zaika, A., Puolakkainen, P., Nagy, B., Madrigal, I., Kokkola, A., Väyrynen, A., Kärkkäinen, P., Moskaluk, C., El-Rifai, W., Knuutila, S. Int. J. Cancer (2004)
- DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma. Ebihara, Y., Miyamoto, M., Fukunaga, A., Kato, K., Shichinohe, T., Kawarada, Y., Kurokawa, T., Cho, Y., Murakami, S., Uehara, H., Kaneko, H., Hashimoto, H., Murakami, Y., Itoh, T., Okushiba, S., Kondo, S., Katoh, H. Br. J. Cancer (2004)
- Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. Beckler, A., Moskaluk, C.A., Zaika, A., Hampton, G.M., Powell, S.M., Frierson, H.F., El-Rifai, W. Cancer (2003)
- Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. Meister, B., Askergren, J., Tunevall, G., Hemmings, H.C., Greengard, P. J. Endocrinol. Invest. (1991)
- Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Bibb, J.A., Snyder, G.L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A.A., Tsai, L.H., Kwon, Y.T., Girault, J.A., Czernik, A.J., Huganir, R.L., Hemmings, H.C., Nairn, A.C., Greengard, P. Nature (1999)
- Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Halpain, S., Girault, J.A., Greengard, P. Nature (1990)
- DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Hemmings, H.C., Greengard, P., Tung, H.Y., Cohen, P. Nature (1984)
- DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia. Håkansson, K., Lindskog, M., Pozzi, L., Usiello, A., Fisone, G. Parkinsonism Relat. Disord. (2004)
- Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1. Hansen, C., Greengard, P., Nairn, A.C., Andersson, T., Vogel, W.F. Exp. Cell Res. (2006)
- Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. El-Rifai, W., Smith, M.F., Li, G., Beckler, A., Carl, V.S., Montgomery, E., Knuutila, S., Moskaluk, C.A., Frierson, H.F., Powell, S.M. Cancer Res. (2002)
- D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin. Mayerhofer, A., Fritz, S., Grünert, R., Sanders, S.L., Duffy, D.M., Ojeda, S.R., Stouffer, R.L. J. Clin. Endocrinol. Metab. (2000)
- Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. Meister, B., Schultzberg, M., Hemmings, H.C., Greengard, P., Goldstein, M., Hökfelt, T. J. Auton. Nerv. Syst. (1991)
- Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells. Endo, S., Suzuki, M., Sumi, M., Nairn, A.C., Morita, R., Yamakawa, K., Greengard, P., Ito, M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. Kwon, Y.G., Huang, H.B., Desdouits, F., Girault, J.A., Greengard, P., Nairn, A.C. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. Brené, S., Lindefors, N., Ehrlich, M., Taubes, T., Horiuchi, A., Kopp, J., Hall, H., Sedvall, G., Greengard, P., Persson, H. J. Neurosci. (1994)
- Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. Mayerhofer, A., Hemmings, H.C., Snyder, G.L., Greengard, P., Boddien, S., Berg, U., Brucker, C. J. Clin. Endocrinol. Metab. (1999)
- DARPP-32: an integrator of neurotransmission. Svenningsson, P., Nishi, A., Fisone, G., Girault, J.A., Nairn, A.C., Greengard, P. Annu. Rev. Pharmacol. Toxicol. (2004)
- Parkin potentiates ATP-induced currents due to activation of P2X receptors in PC12 cells. Sato, A., Arimura, Y., Manago, Y., Nishikawa, K., Aoki, K., Wada, E., Suzuki, Y., Osaka, H., Setsuie, R., Sakurai, M., Amano, T., Aoki, S., Wada, K., Noda, M. J. Cell. Physiol. (2006)
- Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas. Maqani, N., Belkhiri, A., Moskaluk, C., Knuutila, S., Dar, A.A., El-Rifai, W. Mol. Cancer Res. (2006)
- Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain. Donohue, T., Hoffman, P.L., Tabakoff, B. Alcohol. Clin. Exp. Res. (2005)
- Dopaminergic control of synaptic plasticity in the dorsal striatum. Centonze, D., Picconi, B., Gubellini, P., Bernardi, G., Calabresi, P. Eur. J. Neurosci. (2001)