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Gene Review

TNS1  -  tensin 1

Bos taurus

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High impact information on TNS

  • Here, we have examined the binding of a nonspecific hydrophobic fluorescent probe molecule TNS (toluidinylnaphthalenesulfonate) and of felodipine to CAM and several of its proteolytic fragments [1].
  • Furthermore, felodipine exhibits selectivity over TNS and trifluoperazine (TFP) in blocking the tryptic cleavage between residues 77 and 78 [1].
  • 4. In the presence of rawolscine or idazoxan, agmatine produced a concentration-dependent delayed facilitation of TNS-induced contractions, which was prevented by cocaine [2].
  • Extrinsic fluorescence probes, TNS (6-(p-toluidinyl) naphthalene-2-sulfonate) and MIANS (6-(4'-maleimidyl-anilino) naphthalene-2-sulfonic acid), indicated changes in both TNS binding sites and the sulfhydryl groups to a less hydrophobic microenvironment [3].
  • Since TNS binds preferentially to the hydrophobic region of a protein molecule, glycosylation caused an apparent increase in the available hydrophobic sites for the dye [4].

Associations of TNS with chemical compounds

  • 3. Agmatine (0.03-1 mM) produced a concentration-dependent transient inhibition of the contractions induced by transmural nerve stimulation (TNS; 200 mA, 0.2 ms, 1 Hz, 10 s) [2].

Analytical, diagnostic and therapeutic context of TNS

  • A polymethylmethacrylate total artificial heart (kinetic components made of polyetherurethane) of TNS Brno II type was implanted into seven calves (2-5 months of age) surviving for the average of 152.4 +/- 19.1 days after the implantation [5].


  1. Localization of a felodipine (dihydropyridine) binding site on calmodulin. Johnson, J.D., Wittenauer, L.A., Thulin, E., Forsén, S., Vogel, H.J. Biochemistry (1986) [Pubmed]
  2. Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery. González, C., Regunathan, S., Reis, D.J., Estrada, C. Br. J. Pharmacol. (1996) [Pubmed]
  3. Change in the protein tertiary structure with non-enzymatic glycosylation of calf alpha-crystallin. Liang, J.N., Chylack, L.T. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  4. Polar-apolar characteristics and fibrillogenesis of glycosylated collagen. Amudeswari, S., Liang, J.N., Chakrabarti, B. Coll. Relat. Res. (1987) [Pubmed]
  5. Hematological and biochemical studies in calves living over 100 days with the polymethylmethacrylate total artificial heart TNS Brno II. Dostál, M., Vasků, J., Cerný, J., Sotolová, O., Guba, P., Vasků, J., Urbánek, P., Pavlícek, V., Vasků, A., Necas, J. The International journal of artificial organs. (1986) [Pubmed]
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