Disease relevance of Heart, Artificial

• METHODS: We analyzed data from 37 patients admitted from 1981 to 1991 who fulfilled four criteria (age > 16 years, microangiopathic hemolytic anemia, creatinine level > 150 mumol/L [> 1.7 mg/dL], and no artificial heart valve) [1].
• Fondaparinux and subcutaneously administered enoxaparin were as effective as intravenously administered unfractionated heparin in preventing thrombus formation on artificial heart valve leaflets in our investigation [2].
• Sulphinpyrazone normalises the shortened platelet survival associated with gout or artificial heart valves and has shown benefit in secondary prevention of myocardial infarction [3].
• Venous hypertension after total artificial heart (TAH) replacement, a common problem in humans as well as experimental animals, is thought to be related to reduced release of atrial natriuretic factor (ANF) due to atrial damage [4].
• A 40-year-old woman was maintained on a mini Jarvik-7 total artificial heart for 45 days, during which time she recovered from a viral cardiomyopathy and multiple organ failure [5].

High impact information on Heart, Artificial

• Calcification inside artificial hearts: inhibition by warfarin-sodium [6].
• A 44-year-old man with end-stage ischemic cardiomyopathy was supported with an intra-aortic balloon and The Penn State Heart (artificial) prior to orthotopic cardiac transplantation on the 14th hospital day [7].
• Combined use of warfarin and adjusted subcutaneous heparin during pregnancy in patients with an artificial heart valve [8].
• CONCLUSIONS: In humans with a total artificial heart, remifentanil induces a systemic arterial vasodilation without significant effect on the capacitance vessels [9].
• Remifentanil induces systemic arterial vasodilation in humans with a total artificial heart [9].

Chemical compound and disease context of Heart, Artificial

• CONCLUSION: Clopidogrel and aspirin were more effective than warfarin in preventing thrombus formation on artificial heart valve leaflets in our investigation [10].

Biological context of Heart, Artificial

• To assess the effects of endothelin 1 (ET) on the pulmonary and systemic vascular beds simultaneously, we examined the hemodynamic responses to ET in awake calves implanted with a Jarvik total artificial heart (TAH), a device that maintains constant cardiac output (CO) [11].
• Early years of artificial organs at the Cleveland Clinic: Part II: open heart surgery and artificial hearts [12].
• Evaluation of the peripheral effects of dopamine and isoproterenol on the systemic and pulmonary circulation by using total artificial heart [13].
• We examined whether replacement of cardiac atria and ventricles with total artificial hearts (TAH), a procedure that removes cardiac nerves and all sources of atrial natriuretic factor (ANF), would cause alterations in volume homeostasis in awake calves [14].

Anatomical context of Heart, Artificial

• Ventricles made from segmented polyurethane membranes and used in the fabrication of a totally implantable artificial heart are known to undergo biomaterial-associated calcification [15].

Associations of Heart, Artificial with chemical compounds

• Hemodynamic effects of epinephrine, dopamine, nitroglycerin, and nitroprusside in a patient with a total artificial heart (TAH) [16].
• Peripheral vascular effects of thiopental and propofol in humans with artificial hearts [17].
• The peripheral vascular effects of thiopental 5 mg/kg and propofol 2.5 mg/kg were compared in five patients whose lungs were being ventilated and in whom a Jarvik-7 artificial heart had been implanted [17].
• Peripheral vascular effects of halothane and isoflurane in humans with an artificial heart [18].
• Peripheral vascular and direct cardiac effects of calcium chloride were determined in a new animal model, the unanesthetized calf, before and after replacement of its natural heart (NH) with a pneumatically driven artificial heart (AH) [19].

Gene context of Heart, Artificial

• Measurement of beta-thromboglobulin and platelet factor 4 to follow up patients with artificial heart valves [20].
• In this paper we investigate the biostability of a series of Biolon blood sacs that were utilized in electric total artificial hearts for time periods of up to 19 weeks [21].
• The data presented are a brief summary of The International Registry for Mechanical Ventricular Assist Pumps and Artificial Hearts and a summary of the personal experience of the Minnesota Thoracic Associates at the Minneapolis Heart Institute with the use of the Sams centrifugal pump from May 1985 to September 1994 [22].
• Static state hemodynamic variables estimation model for the moving-actuator type total artificial heart. Part. I--cardiac output estimation [23].
• A polymethylmethacrylate total artificial heart (kinetic components made of polyetherurethane) of TNS Brno II type was implanted into seven calves (2-5 months of age) surviving for the average of 152.4 +/- 19.1 days after the implantation [24].

Analytical, diagnostic and therapeutic context of Heart, Artificial

• In four control implants the blood sacs and cannulas were fabricated from Ethicon's Biomer segmented polyurethane, which is the present clinical standard for most artificial hearts and circulatory support devices [25].
• Plasma atrial natriuretic peptide (ANP) concentrations were measured by radioimmunoassay 1 to 12 days after operation in six patients with artificial hearts [26].
• This investigation was designed to develop a satisfactory PTC for conveying large bore cannulae as required for current use with the artificial heart and left heart assist device [27].
• The total artificial heart has been used as a bridge to transplantation in three patients with terminal cardiomyopathy [28].

References