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Gene Review

Tns1  -  tensin 1

Mus musculus

Synonyms: 1110018I21Rik, 1200014E20Rik, AI648117, E030018G17Rik, E030037J05Rik, ...
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Disease relevance of Tns1

  • Mice with overt signs of weakness exhibited signs of renal failure and possessed multiple large cysts in the proximal kidney tubules, but even in tensin null mice with normal blood analysis, cysts were prevalent [1].
  • Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity [2].
  • In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal involvement [3].
  • Focusing on a candidate transcript that has not been previously linked to hypertrophy, we found that protein levels of the tumor suppressor PTEN (phosphatase and tensin homologue on chromosome ten) were increased in the absence of increased messenger RNA levels [4].
  • Mutations of the 'phosphatase and tensin homologue deleted on chromosome 10' (PTEN/MMAC1) gene have been associated with a variety of human cancers, including prostate cancer, glioblastoma, and melanoma [5].

High impact information on Tns1

  • PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation [6].
  • The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin [7].
  • The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases [8].
  • Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a complex signaling system that affects a variety of important cell functions [9].
  • Tyrosine phosphorylation of Cas, paxillin, and tensin were markedly decreased in VSMCs expressing KI-Src and in src-/- VSMCs [10].

Biological context of Tns1


Anatomical context of Tns1

  • Taken together, our data imply that, in the kidney, loss of tensin leads to a weakening, rather than a severing, of focal adhesion [1].
  • Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways [13].
  • Negative regulation of phosphatidylinositol 3-kinase signaling and IL-2-mediated proliferation of CD4(+)CD25(+) T cells is inversely associated with expression of the phosphatase and tensin homologue deleted on chromosome 10, PTEN [14].
  • These results suggest that PI 3-kinase interacts with the cytoskeleton via the SH2 domain of tensin and may play an important role in platelet-derived growth factor-induced cytoskeletal reorganization that is concomitant with cell migration and proliferation [15].
  • Tensin, which normally segregates into fibrillar adhesions was localized in large focal contacts in the two mutant cell lines, suggesting involvement of pp60(c-src) in the segregation of focal contacts and fibrillar adhesions [16].

Associations of Tns1 with chemical compounds


Physical interactions of Tns1


Enzymatic interactions of Tns1

  • After confirming the efficiency of glucosylated PEI carriers in lungs, the potential effects of the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene on Akt downstream pathways were investigated [21].
  • A most notable finding is that tumorigenesis is accompanied by inactivation of phosphatase and tensin homolog deleted on chromosome 10 (Pten), activation of AKT, fast proliferation and nuclear accumulation of cyclin D1 [22].
  • Phagosomes containing IgG-coated particles accumulated 3'-phosphatase and tensin homologue deleted on chromosome 10 and Src homology 2 domain-containing inositol 5'-phosphatase, yet Hp phagosomes did not [23].

Other interactions of Tns1

  • Pten (phosphatase with tensin homology), a dual-specificity phosphatase, is a negative regulator of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway [24].
  • Overexpression of a dominant negative Akt mutant or of the tumor suppressor phosphatase and tensin homologue, PTEN, in these cells also caused a significant reduction in MT1-MMP expression and invasion [25].
  • The focal adhesion kinase (FAK) functions in regulating tyrosine phosphorylation of several of these proteins, including paxillin, tensin, and p130(cas) [26].
  • Moreover, treatment of wild-type cells with tyrphostin AG1007, which inhibits both pp60(c-src) and FAK activity, induced accumulation of tensin in peripheral focal adhesions [16].
  • In order to determine the role of pp60(c-src) and related kinases in these processes, we have compared the dynamic reorganization of phosphotyrosine, vinculin, focal adhesion kinase and tensin in cells with altered expression of Src-family kinases [16].

Analytical, diagnostic and therapeutic context of Tns1

  • To explore the biological functions of tensin, we cloned the mouse tensin gene, determined its program of expression, and used gene targeting to generate mice lacking tensin [1].


  1. Progressive kidney degeneration in mice lacking tensin. Lo, S.H., Yu, Q.C., Degenstein, L., Chen, L.B., Fuchs, E. J. Cell Biol. (1997) [Pubmed]
  2. Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Wong, J.T., Kim, P.T., Peacock, J.W., Yau, T.Y., Mui, A.L., Chung, S.W., Sossi, V., Doudet, D., Green, D., Ruth, T.J., Parsons, R., Verchere, C.B., Ong, C.J. Diabetologia (2007) [Pubmed]
  3. PTEN-deficient intestinal stem cells initiate intestinal polyposis. He, X.C., Yin, T., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L.M., Barrett, T.A., Hood, L., Wu, H., Li, L. Nat. Genet. (2007) [Pubmed]
  4. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. Schwartzbauer, G., Robbins, J. J. Biol. Chem. (2001) [Pubmed]
  5. PTEN gene loss, but not mutation, in benign and malignant phaeochromocytomas. van Nederveen, F.H., Perren, A., Dannenberg, H., Petri, B.J., Dinjens, W.N., Komminoth, P., de Krijger, R.R. J. Pathol. (2006) [Pubmed]
  6. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Stambolic, V., Suzuki, A., de la Pompa, J.L., Brothers, G.M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J.M., Siderovski, D.P., Mak, T.W. Cell (1998) [Pubmed]
  7. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D.H., Tavtigian, S.V. Nat. Genet. (1997) [Pubmed]
  8. The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling. Hagenbeek, T.J., Naspetti, M., Malergue, F., Garçon, F., Nunès, J.A., Cleutjens, K.B., Trapman, J., Krimpenfort, P., Spits, H. J. Exp. Med. (2004) [Pubmed]
  9. Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. Kwak, Y.G., Song, C.H., Yi, H.K., Hwang, P.H., Kim, J.S., Lee, K.S., Lee, Y.C. J. Clin. Invest. (2003) [Pubmed]
  10. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. Ishida, T., Ishida, M., Suero, J., Takahashi, M., Berk, B.C. J. Clin. Invest. (1999) [Pubmed]
  11. Signalling through Class I PI3Ks in mammalian cells. Hawkins, P.T., Anderson, K.E., Davidson, K., Stephens, L.R. Biochem. Soc. Trans. (2006) [Pubmed]
  12. Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. Zhao, H., Cui, Y., Dupont, J., Sun, H., Hennighausen, L., Yakar, S. Cancer Res. (2005) [Pubmed]
  13. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Chen, H., Duncan, I.C., Bozorgchami, H., Lo, S.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. Bensinger, S.J., Walsh, P.T., Zhang, J., Carroll, M., Parsons, R., Rathmell, J.C., Thompson, C.B., Burchill, M.A., Farrar, M.A., Turka, L.A. J. Immunol. (2004) [Pubmed]
  15. Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes. Auger, K.R., Songyang, Z., Lo, S.H., Roberts, T.M., Chen, L.B. J. Biol. Chem. (1996) [Pubmed]
  16. pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions. Volberg, T., Romer, L., Zamir, E., Geiger, B. J. Cell. Sci. (2001) [Pubmed]
  17. Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Chiang, M.K., Liao, Y.C., Kuwabara, Y., Lo, S.H. Dev. Biol. (2005) [Pubmed]
  18. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. Cao, X., Wei, G., Fang, H., Guo, J., Weinstein, M., Marsh, C.B., Ostrowski, M.C., Tridandapani, S. J. Immunol. (2004) [Pubmed]
  19. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. Kushner, J.A., Simpson, L., Wartschow, L.M., Guo, S., Rankin, M.M., Parsons, R., White, M.F. J. Biol. Chem. (2005) [Pubmed]
  20. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation. Lee, K.S., Kim, S.R., Park, S.J., Lee, H.K., Park, H.S., Min, K.H., Jin, S.M., Lee, Y.C. Mol. Pharmacol. (2006) [Pubmed]
  21. Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice. Kim, H.W., Park, I.K., Cho, C.S., Lee, K.H., Beck, G.R., Colburn, N.H., Cho, M.H. Cancer Res. (2004) [Pubmed]
  22. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Qiao, W., Li, A.G., Owens, P., Xu, X., Wang, X.J., Deng, C.X. Oncogene (2006) [Pubmed]
  23. Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori. Allen, L.A., Allgood, J.A., Han, X., Wittine, L.M. J. Leukoc. Biol. (2005) [Pubmed]
  24. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Wijesekara, N., Konrad, D., Eweida, M., Jefferies, C., Liadis, N., Giacca, A., Crackower, M., Suzuki, A., Mak, T.W., Kahn, C.R., Klip, A., Woo, M. Mol. Cell. Biol. (2005) [Pubmed]
  25. Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling. Zhang, D., Brodt, P. Oncogene (2003) [Pubmed]
  26. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. Shen, Y., Schneider, G., Cloutier, J.F., Veillette, A., Schaller, M.D. J. Biol. Chem. (1998) [Pubmed]
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