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Gene Review

GPS1  -  G protein pathway suppressor 1

Homo sapiens

Synonyms: COP9 signalosome complex subunit 1, COPS1, CSN1, GPS-1, JAB1-containing signalosome subunit 1, ...
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Disease relevance of GPS1

  • In this study, we investigated 35 fibrohistiocytic tumors of the skin of benign, intermediate and malignant potential from 32 patients: 15 fibrous histiocytomas (FH), 5 FH with atypia (AFH), 7 atypical fibroxanthomas (AFX), 5 dermatofibrosarcoma protuberans (DFSP) and 3 malignant FH (MFH) [1].

High impact information on GPS1

  • Pcu4, Csn1, and Csn2 promote the degradation of Spd1, identifying a new function for the signalosome as a regulator of Pcu4-containing E3 ubiquitin ligase [2].
  • For gps1, these results are consistent with the proposed function of FUS6 (COP11) as a signal transduction repressor in plants [3].
  • A chimeric construct containing gps1 and FUS6 sequences also suppressed the yeast pheromone pathway, indicating functional conservation between these human and plant genes [3].
  • In addition, the inositol kinase activity of 5/6-kinase is inhibited when in a complex with CSN1 [4].
  • Eight subunits (Sgn1-Sgn8) of the homologous mammalian complex have been purified [3] [4] [5].

Biological context of GPS1

  • DNA from one of the CSN/BAC clones was used as a probe for in situ hybridization to show that the CSN1 and CSN2 gene cluster is located on chromosome 15 band q23 and not on chromosome 12 as had been previously reported [6].
  • By differential screening of a rat pineal cDNA library we identified earlier a novel transcript having a 57% nucleotide homology and a 45% amino acid identity with a plant fusca-gene (fus6) to which a corresponding human sequence (gps1) has recently been reported [7].

Associations of GPS1 with chemical compounds

  • MEASUREMENTS: Alcohol compliance checks and Cops in Shops programs were the primary outcomes [8].

Other interactions of GPS1

  • In this study, we dissected structure and function of the subunit 1 (CSN1 or GPS1) of the COP9 signalosome relative to the complex [9].
  • Several casein (CSN) genes (CSN1, 2, 10 and alphas2-CSN) have been described and shown to be clustered in mouse, man and cattle [6].

Analytical, diagnostic and therapeutic context of GPS1

  • Sequence analysis indicated that gps1-1 contains only the carboxy-terminal half of the gps1 coding sequence [3].
  • Herein, using differential display PCR, we have cloned an 85-kDa forkhead transcription factor (termed Mac-1-regulated forkhead [MFH] and found subsequently to be identical to Foxp1) that is downregulated in beta(2)-integrin Mac-1-clustered compared with Mac-1-nonclustered monocytic THP-1 cells [10].
  • Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7) [11].


  1. Nucleolar organizer regions in fibrohistiocytic tumors of the skin. Merot, Y., Durgniat, A.C., Frenk, E. J. Cutan. Pathol. (1990) [Pubmed]
  2. Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms. Liu, C., Powell, K.A., Mundt, K., Wu, L., Carr, A.M., Caspari, T. Genes Dev. (2003) [Pubmed]
  3. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Spain, B.H., Bowdish, K.S., Pacal, A.R., Staub, S.F., Koo, D., Chang, C.Y., Xie, W., Colicelli, J. Mol. Cell. Biol. (1996) [Pubmed]
  4. Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. Sun, Y., Wilson, M.P., Majerus, P.W. J. Biol. Chem. (2002) [Pubmed]
  5. The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Mundt, K.E., Porte, J., Murray, J.M., Brikos, C., Christensen, P.U., Caspari, T., Hagan, I.M., Millar, J.B., Simanis, V., Hofmann, K., Carr, A.M. Curr. Biol. (1999) [Pubmed]
  6. Structure of the rabbit alphas1- and beta-casein gene cluster, assignment to chromosome 15 and expression of the alphas1-casein gene in HC11 cells. Pauloin, A., Rogel-Gaillard, C., Piumi, F., Hayes, H., Fontaine, M.L., Chanat, E., Chardon, P., Devinoy, E. Gene (2002) [Pubmed]
  7. A fusca gene homologue in mammalian tissues: Developmental regulation in the rat testes. Nitz, B., Ivell, R., Hartung, S., Middendorff, R., Olcese, J. Mol. Cell. Endocrinol. (1998) [Pubmed]
  8. Enforcing the minimum drinking age: state, local and agency characteristics associated with compliance checks and Cops in Shops programs. Montgomery, J.M., Foley, K.L., Wolfson, M. Addiction (2006) [Pubmed]
  9. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. Tsuge, T., Matsui, M., Wei, N. J. Mol. Biol. (2001) [Pubmed]
  10. Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. Shi, C., Zhang, X., Chen, Z., Sulaiman, K., Feinberg, M.W., Ballantyne, C.M., Jain, M.K., Simon, D.I. J. Clin. Invest. (2004) [Pubmed]
  11. Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7). Dessau, M., Chamovitz, D.A., Hirsch, J.A. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
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