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Gene Review

Itgam  -  integrin alpha M

Mus musculus

Synonyms: CD11 antigen-like family member B, CD11B (p170), CD11b/CD18, CR-3 alpha chain, CR3, ...
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Disease relevance of Itgam


High impact information on Itgam


Chemical compound and disease context of Itgam


Biological context of Itgam


Anatomical context of Itgam


Associations of Itgam with chemical compounds


Physical interactions of Itgam

  • No changes in the expression of vascular addressins, VCAM-1, E selection or ICAM-1 could be observed but the binding of monocytes could be blocked with an antibody against Mac-1 [24].
  • Furthermore, suppression was not limited to Fc receptor-mediated phagocytosis because binding and uptake of C3bi-opsonized SRBCs to CR3 receptors was also decreased following LPS treatment [25].
  • Mitogenesis was not inhibited by monoclonal antibodies specific for class I major histocompatibility complex antigens or monoclonal antibodies specific for Mac-1, Lyt-1, or Lyt-2 cell surface proteins [26].

Regulatory relationships of Itgam

  • Treatment with mAb to LFA-1 blocked 78% of neutrophil accumulation in Mac-1-deficient mice and 58% in wild-type mice [27].
  • Host immune cells use type 3 complement receptors (CR3) to regulate excess TNF-alpha production during physiological clearance of apoptotic cells [28].
  • Localization of sialidase-positive cells expressing Mac-1 and immunoglobulin in the mouse thymus [29].
  • Elastase release in the inflamed tissue was reduced in Mac-1-deficient mice, and a deficiency of Mac-1 or the kinases blocked neutrophil elastase release in vitro [30].
  • In contrast, C71/26 and other MoAbs against Pgp-1 inhibited platelet-dependent cytotoxicity of antibody-coated sheep erythrocytes in the presence of C5-deficient mouse plasma whereas M1/70 against CR3 showed no effect [31].

Other interactions of Itgam


Analytical, diagnostic and therapeutic context of Itgam


  1. Regulation of interleukin-12 by complement receptor 3 signaling. Marth, T., Kelsall, B.L. J. Exp. Med. (1997) [Pubmed]
  2. Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock. Jaeschke, H., Essani, N.A., Fisher, M.A., Vonderfecht, S.L., Farhood, A., Smith, C.W. Hepatology (1996) [Pubmed]
  3. Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis. Bullard, D.C., Hu, X., Schoeb, T.R., Axtell, R.C., Raman, C., Barnum, S.R. J. Immunol. (2005) [Pubmed]
  4. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. Prince, J.E., Brayton, C.F., Fossett, M.C., Durand, J.A., Kaplan, S.L., Smith, C.W., Ballantyne, C.M. J. Immunol. (2001) [Pubmed]
  5. Stepwise reprogramming of B cells into macrophages. Xie, H., Ye, M., Feng, R., Graf, T. Cell (2004) [Pubmed]
  6. The clearance mechanism of chilled blood platelets. Hoffmeister, K.M., Felbinger, T.W., Falet, H., Denis, C.V., Bergmeier, W., Mayadas, T.N., von Andrian, U.H., Wagner, D.D., Stossel, T.P., Hartwig, J.H. Cell (2003) [Pubmed]
  7. Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus. Ockenhouse, C.F., Betageri, R., Springer, T.A., Staunton, D.E. Cell (1992) [Pubmed]
  8. Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages. Hutchings, P., Rosen, H., O'Reilly, L., Simpson, E., Gordon, S., Cooke, A. Nature (1990) [Pubmed]
  9. The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury. Gozes, I., Zaltzman, R., Hauser, J., Brenneman, D.E., Shohami, E., Hill, J.M. Current Alzheimer research. (2005) [Pubmed]
  10. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. Tang, T., Rosenkranz, A., Assmann, K.J., Goodman, M.J., Gutierrez-Ramos, J.C., Carroll, M.C., Cotran, R.S., Mayadas, T.N. J. Exp. Med. (1997) [Pubmed]
  11. Modulation of endotoxin-induced histamine synthesis by cytokines in mouse bone marrow-derived macrophages. Takamatsu, S., Nakashima, I., Nakano, K. J. Immunol. (1996) [Pubmed]
  12. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). Simon, D.I., Chen, Z., Xu, H., Li, C.Q., Dong, J., McIntire, L.V., Ballantyne, C.M., Zhang, L., Furman, M.I., Berndt, M.C., López, J.A. J. Exp. Med. (2000) [Pubmed]
  13. Listericidal and nonlistericidal mouse macrophages differ in complement receptor type 3-mediated phagocytosis of L. monocytogenes and in preventing escape of the bacteria into the cytoplasm. Drevets, D.A., Canono, B.P., Campbell, P.A. J. Leukoc. Biol. (1992) [Pubmed]
  14. Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon. Springer, T.A., Teplow, D.B., Dreyer, W.J. Nature (1985) [Pubmed]
  15. Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. Sanchez-Madrid, F., Simon, P., Thompson, S., Springer, T.A. J. Exp. Med. (1983) [Pubmed]
  16. Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). Ding, A., Wright, S.D., Nathan, C. J. Exp. Med. (1987) [Pubmed]
  17. Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1. Dunne, J.L., Ballantyne, C.M., Beaudet, A.L., Ley, K. Blood (2002) [Pubmed]
  18. Functional association of CD9 with the Fc gamma receptors in macrophages. Kaji, K., Takeshita, S., Miyake, K., Takai, T., Kudo, A. J. Immunol. (2001) [Pubmed]
  19. Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. Panopoulos, A.D., Bartos, D., Zhang, L., Watowich, S.S. J. Biol. Chem. (2002) [Pubmed]
  20. The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. Sastre, L., Kishimoto, T.K., Gee, C., Roberts, T., Springer, T.A. J. Immunol. (1986) [Pubmed]
  21. Chemical-induced hippocampal neurodegeneration and elevations in TNFalpha, TNFbeta, IL-1alpha, IP-10, and MCP-1 mRNA in osteopetrotic (op/op) mice. Bruccoleri, A., Harry, G.J. J. Neurosci. Res. (2000) [Pubmed]
  22. Mechanism of Enhanced Hematopoietic Response by Soluble beta-Glucan SCG in Cyclophosphamide-Treated Mice. Harada, T., Kawaminami, H., Miura, N.N., Adachi, Y., Nakajima, M., Yadomae, T., Ohno, N. Microbiol. Immunol. (2006) [Pubmed]
  23. MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity. Pei, Z., Pang, H., Qian, L., Yang, S., Wang, T., Zhang, W., Wu, X., Dallas, S., Wilson, B., Reece, J.M., Miller, D.S., Hong, J.S., Block, M.L. Glia (2007) [Pubmed]
  24. Activation of high endothelial venules in peripheral lymph nodes. The involvement of interferon-gamma. Kraal, G., Schornagel, K., Savelkoul, H., Maruyama, T. Int. Immunol. (1994) [Pubmed]
  25. Lipopolysaccharide-induced suppression of erythrocyte binding and phagocytosis via Fc gamma RI, Fc gamma RII, Fc gamma RIII, and CR3 receptors in murine macrophages. Sundaram, R., O'Connor, M., Cicero, M., Ghaffar, A., Gangemi, J.D., Mayer, E.P. J. Leukoc. Biol. (1993) [Pubmed]
  26. Cell surface molecules involved in early events in T-cell mitogenic stimulation by staphylococcal enterotoxins. Vroegop, S.M., Buxser, S.E. Infect. Immun. (1989) [Pubmed]
  27. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. Lu, H., Smith, C.W., Perrard, J., Bullard, D., Tang, L., Shappell, S.B., Entman, M.L., Beaudet, A.L., Ballantyne, C.M. J. Clin. Invest. (1997) [Pubmed]
  28. Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection. Brandhorst, T.T., Wüthrich, M., Finkel-Jimenez, B., Warner, T., Klein, B.S. J. Immunol. (2004) [Pubmed]
  29. Localization of sialidase-positive cells expressing Mac-1 and immunoglobulin in the mouse thymus. Kijimoto-Ochiai, S., Doi, N., Matsukawa, H., Fujii, M., Tomobe, K. Glycoconj. J. (2004) [Pubmed]
  30. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Hirahashi, J., Mekala, D., Van Ziffle, J., Xiao, L., Saffaripour, S., Wagner, D.D., Shapiro, S.D., Lowell, C., Mayadas, T.N. Immunity (2006) [Pubmed]
  31. Polymorphic glycoprotein-1 on mouse platelets: possible role of Pgp-1 and LFA-1 in antibody-dependent platelet cytotoxicity involving complement. McCaffery, P.J., Tan, A.S., Berridge, M.V. Blood (1987) [Pubmed]
  32. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. Xu, H., Gonzalo, J.A., St Pierre, Y., Williams, I.R., Kupper, T.S., Cotran, R.S., Springer, T.A., Gutierrez-Ramos, J.C. J. Exp. Med. (1994) [Pubmed]
  33. Dectin-1 is a major beta-glucan receptor on macrophages. Brown, G.D., Taylor, P.R., Reid, D.M., Willment, J.A., Williams, D.L., Martinez-Pomares, L., Wong, S.Y., Gordon, S. J. Exp. Med. (2002) [Pubmed]
  34. Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis. Wang, C., Hayashi, H., Harrison, R., Chiu, B., Chan, J.R., Ostergaard, H.L., Inman, R.D., Jongstra, J., Cybulsky, M.I., Jongstra-Bilen, J. J. Immunol. (2002) [Pubmed]
  35. Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion. Arumugam, T.V., Salter, J.W., Chidlow, J.H., Ballantyne, C.M., Kevil, C.G., Granger, D.N. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  36. Complement receptor type 3 mediates phagocytosis and killing of Listeria monocytogenes by a TNF-alpha- and IFN-gamma-stimulated macrophage precursor hybrid. Drevets, D.A., Leenen, P.J., Campbell, P.A. Cell. Immunol. (1996) [Pubmed]
  37. Surfactant protein A modulates cell surface expression of CR3 on alveolar macrophages and enhances CR3-mediated phagocytosis. Gil, M., McCormack, F.X., Levine, A.M. J. Biol. Chem. (2009) [Pubmed]
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