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Gene Review

GPS2  -  G protein pathway suppressor 2

Homo sapiens

Synonyms: GPS-2
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Disease relevance of GPS2


High impact information on GPS2

  • We report here that GPS2, a protein involved in intracellular signaling, is an integral subunit of the N-CoR-HDAC3 complex [2].
  • AMF1 (GPS2) modulates p53 transactivation [3].
  • Overexpression of AMF1 in U2OS cells increases basal level p21(WAF1/CIP1) expression and causes a G(1) arrest [3].
  • U2OS cells stably overexpressing AMF1 show increased apoptosis upon exposure to UV irradiation [3].
  • These observations led us to test whether AMF1 regulates the functions of p53, a critical transcriptional activator that integrates stress signals and regulates cell cycle and programmed cell death [3].

Biological context of GPS2

  • GPS2 represents a new molecule that could contribute important insights toward how cytokine- and oncoprotein-mediated signal transduction might converge [1].
  • In the present study, we found that the zinc finger proteins showed the same DNA-binding affinities to GPS2 [4].
  • In wild-type cells, expression of either gps1-1 or gps2 led to enhanced recovery from cell cycle arrest induced by pheromone [5].
  • Western blotting using antibody against acetyl-lysine failed to detect acetylation of AMF-1 or E2 in complex with p300 [6].
  • The cellular protein AMF-1 (Gps2) positively modulates gene expression by the papillomavirus E2 protein (D. E. Breiding et al., Mol. Cell. Biol. 17:7208-7219, 1997) [6].

Other interactions of GPS2

  • Together, the results of our present study suggest that the GPS2-associated deacetylase complex might function in concert with hMSH4-hMSH5 during the process of homologous recombination [7].
  • Alternatively, it is not excluded that GPS2 could work in a parallel pathway that leads from TNFalpha to JNK1 [1].
  • We have isolated two novel human cDNAs, gps1-1 and gps2, that suppress lethal G-protein subunit-activating mutations in the pheromone response pathway of the yeast Saccharomyces cerevisiae [5].


  1. A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. Jin, D.Y., Teramoto, H., Giam, C.Z., Chun, R.F., Gutkind, J.S., Jeang, K.T. J. Biol. Chem. (1997) [Pubmed]
  2. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Zhang, J., Kalkum, M., Chait, B.T., Roeder, R.G. Mol. Cell (2002) [Pubmed]
  3. AMF1 (GPS2) modulates p53 transactivation. Peng, Y.C., Kuo, F., Breiding, D.E., Wang, Y.F., Mansur, C.P., Androphy, E.J. Mol. Cell. Biol. (2001) [Pubmed]
  4. Functional analysis of zinc finger proteins that bind to the silencer element in the glutathione transferase P gene. Tanabe, A., Kurita, M., Oshima, K., Osada, S., Nishihara, T., Imagawa, M. Biol. Pharm. Bull. (2002) [Pubmed]
  5. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Spain, B.H., Bowdish, K.S., Pacal, A.R., Staub, S.F., Koo, D., Chang, C.Y., Xie, W., Colicelli, J. Mol. Cell. Biol. (1996) [Pubmed]
  6. AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. Peng, Y.C., Breiding, D.E., Sverdrup, F., Richard, J., Androphy, E.J. J. Virol. (2000) [Pubmed]
  7. Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment. Lee, T.H., Yi, W., Griswold, M.D., Zhu, F., Her, C. DNA Repair (Amst.) (2006) [Pubmed]
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