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Gene Review:

Bzrap1 - benzodiazepine receptor (peripheral)...

Rattus norvegicus

Synonyms: PRAX-1, Peripheral-type benzodiazepine receptor-associated protein 1, RIM-BP1, RIMS-binding protein 1, Rbp1

Chardenot, P. et al.

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Psychiatry related information on Bzrap1

Repeated electroconvulsive shock administration significantly enhanced PRAX1 expression in the CA1 subfield and dentate gyrus [1].

High impact information on Bzrap1

Long-term treatments (21 days) with the neuroleptic haloperidol increased PRAX-1 mRNA expression only in the dentate gyrus, whereas anxiolytic/anticonvulsant diazepam had no effect in any of the hippocampal region studied [1].
Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain [1].
A protein associated with the peripheral-type benzodiazepine receptor (PRAX-1) has recently been cloned, but its regional distribution in the central nervous system and its function remain to be clarified [1].
Furthermore, the selective nonpeptide NK2 receptor antagonist (S)-N-methyl-N-[4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl]benzamide (SR48968), which shows an antidepressant profile in animal studies, also enhanced PRAX-1 mRNA expression [1].
In situ hybridization was carried out to localize PRAX-1 mRNA in the rat brain and revealed a high expression of the transcript in limbic structures such as the CA1 region of the hippocampus, as well as the dentate gyrus, septum, amygdala, and the islands of Calleja [1].

References

Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain. Chardenot, P., Roubert, C., Galiègue, S., Casellas, P., Le Fur, G., Soubrié, P., Oury-Donat, F. Mol. Pharmacol. (2002) [Pubmed]

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