The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tspo  -  translocator protein

Rattus norvegicus

Synonyms: Bzrp, MBR, Mbr, Mitochondrial benzodiazepine receptor, PBR, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bzrp

  • Peripheral-type benzodiazepine receptor (PBR) protein was also increased at 6 and 7 days of age in pups exposed to hypoxia from birth [1].
  • Peripheral benzodiazepine receptor (PBR) expression increases in small dorsal root ganglion (DRG) sensory neurons after peripheral nerve injury [2].
  • In conclusion, our results suggest that enhanced IBP expression, including enhanced PBR ligand binding, such as occurring in untreated C6 glioma cells, may provide a mechanism to increase apoptotic rates of cancer cells [3].
  • We examined the biochemical and ultrastructural alterations in rat liver following experimentally induced acute hepatic porphyria, as well as the effects of the administration of a selective PBR ligand, PK 11195 [4].
  • Stimulation of mitochondrial benzodiazepine receptors (MBRs), which enhances neurosteroid production, by infusions of an MBR agonist to the VTA enhances lordosis [5].

Psychiatry related information on Bzrp


High impact information on Bzrp


Chemical compound and disease context of Bzrp


Biological context of Bzrp


Anatomical context of Bzrp


Associations of Bzrp with chemical compounds

  • However, pretreatment of the rats with N(w)nitro-arginine methylester, which blocked ISO-induced increases in TnNOS, neither restored the T response to human chorionic gonadotropin nor prevented the decreases in StAR and PBR [19].
  • This effect appears to be mediated at least in part by an increase in controllers of mitochondrial cholesterol transport (StAR and PBR) and to occur independently of measurable changes in endogenous plasma ACTH [1].
  • These studies suggest that PKBS comprises binding domains for benzodiazepines and isoquinoline carboxamides and hence is apparently responsible for the manifestation of peripheral-type benzodiazepine recognition sites [16].
  • Cyanogen bromide digestion of purified PKBS yielded several peptide fragments which were subjected to gas-phase sequencing [16].
  • Exposure to ACTH, but not saline, for 1 wk significantly increased adrenal mass, the corticosterone response to ACTH, and the expression of PBR protein and mRNA [17].

Regulatory relationships of Bzrp


Other interactions of Bzrp


Analytical, diagnostic and therapeutic context of Bzrp


  1. Adrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR. Raff, H., Hong, J.J., Oaks, M.K., Widmaier, E.P. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  2. Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mills, C.D., Bitler, J.L., Woolf, C.J. Mol. Cell. Neurosci. (2005) [Pubmed]
  3. The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Levin, E., Premkumar, A., Veenman, L., Kugler, W., Leschiner, S., Spanier, I., Weisinger, G., Lakomek, M., Weizman, A., Snyder, S.H., Pasternak, G.W., Gavish, M. Biochemistry (2005) [Pubmed]
  4. PK 11195 aggravates 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced hepatic porphyria in rats. Fonia, O., Weizman, R., Coleman, R., Kaganovskaya, E., Gavish, M. Hepatology (1996) [Pubmed]
  5. The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents. Frye, C.A. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  6. Increased densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand [3H]PK11195 in vulnerable regions of the rat brain in thiamine deficiency encephalopathy. Leong, D.K., Le, O., Oliva, L., Butterworth, R.F. J. Cereb. Blood Flow Metab. (1994) [Pubmed]
  7. Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Ryu, J.K., Choi, H.B., McLarnon, J.G. Neurobiol. Dis. (2005) [Pubmed]
  8. Targeted molecular imaging agents for cellular-scale bimodal imaging. Manning, H.C., Goebel, T., Thompson, R.C., Price, R.R., Lee, H., Bornhop, D.J. Bioconjug. Chem. (2004) [Pubmed]
  9. Environmentally induced changes in peripheral benzodiazepine receptors are stressor and tissue specific. Drugan, R.C., Holmes, P.V., Scher, D.M., Luczak, S., Oh, H., Ferland, R.J. Pharmacol. Biochem. Behav. (1995) [Pubmed]
  10. Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells. Fischer, R., Schmitt, M., Bode, J.G., Häussinger, D. Gastroenterology (2001) [Pubmed]
  11. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. McEnery, M.W., Snowman, A.M., Trifiletti, R.R., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  12. Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. Kupczyk-Subotkowska, L., Siahaan, T.J., Basile, A.S., Friedman, H.S., Higgins, P.E., Song, D., Gallo, J.M. J. Med. Chem. (1997) [Pubmed]
  13. PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. Veenman, L., Leschiner, S., Spanier, I., Weisinger, G., Weizman, A., Gavish, M. J. Neurochem. (2002) [Pubmed]
  14. Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands. Ratcliffe, S.L., Matthews, E.K. Br. J. Cancer (1995) [Pubmed]
  15. In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters. Petralia, S.M., Frye, C.A. Psychopharmacology (Berl.) (2005) [Pubmed]
  16. Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. Sprengel, R., Werner, P., Seeburg, P.H., Mukhin, A.G., Santi, M.R., Grayson, D.R., Guidotti, A., Krueger, K.E. J. Biol. Chem. (1989) [Pubmed]
  17. Reversible changes in adrenocorticotropin (ACTH)-induced adrenocortical steroidogenesis and expression of the peripheral-type benzodiazepine receptor during the ACTH-insensitive period in young rats. Lee, J.J., Eisenberg, P., Papadopoulos, V., Wang, J., Widmaier, E.P. Endocrinology (2004) [Pubmed]
  18. Structure of the rat gene encoding the mitochondrial benzodiazepine receptor. Casalotti, S.O., Pelaia, G., Yakovlev, A.G., Csikós, T., Grayson, D.R., Krueger, K.E. Gene (1992) [Pubmed]
  19. Activation of a neural brain-testicular pathway rapidly lowers Leydig cell levels of the steroidogenic acute regulatory protein and the peripheral-type benzodiazepine receptor while increasing levels of neuronal nitric oxide synthase. Herman, M., Rivier, C. Endocrinology (2006) [Pubmed]
  20. Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands. Zilz, A., Li, H., Castello, R., Papadopoulos, V., Widmaier, E.P. Endocrinology (1999) [Pubmed]
  21. Proteinaceous complexes from mitochondrial contact sites. Vyssokikh, M.Y., Goncharova, N.Y., Zhuravlyova, A.V., Zorova, L.D., Kirichenko, V.V., Krasnikov, B.F., Kuzminova, A.E., Melikov, K.C., Melik-Nubarov, N.S., Samsonov, A.V., Belousov, V.V., Prischepova, A.E., Zorov, D.B. Biochemistry Mosc. (1999) [Pubmed]
  22. GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding and steroidogenic acute regulatory protein expression during pregnancy. Sridaran, R., Philip, G.H., Li, H., Culty, M., Liu, Z., Stocco, D.M., Papadopoulos, V. J. Mol. Endocrinol. (1999) [Pubmed]
  23. Characterization of prohibitin in a newly established rat ovarian granulosa cell line. Thompson, W.E., Branch, A., Whittaker, J.A., Lyn, D., Zilberstein, M., Mayo, K.E., Thomas, K. Endocrinology (2001) [Pubmed]
  24. Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands. Ostuni, M.A., Marazova, K., Peranzi, G., Vidic, B., Papadopoulos, V., Ducroc, R., Lacapere, J.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  25. Systemic administration of alcohol to adult rats inhibits leydig cell activity: Time course of effect and role of nitric oxide. Herman, M., Kang, S.S., Lee, S., James, P., Rivier, C. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  26. Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites. Antkiewicz-Michaluk, L., Mukhin, A.G., Guidotti, A., Krueger, K.E. J. Biol. Chem. (1988) [Pubmed]
WikiGenes - Universities