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Gene Review

pcaH  -  protocatechuate 3,4-dioxygenase subunit beta

Acinetobacter sp. ADP1

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Disease relevance of pcaH


High impact information on pcaH

  • In an appropriate genetic background, it is possible to select for Acinetobacter strains containing spontaneous mutations blocking expression of pcaH or -G, genes encoding the alpha and beta subunits of protocatechuate 3, 4-dioxygenase [1].
  • To further understand how protein structure influences function, we isolated strains in which the phenotypes of three different deletion mutations in pcaH or -G were suppressed either by a spontaneous mutation or by a PCR-generated random mutation introduced into the Acinetobacter chromosome by natural transformation [1].
  • The pcaG and pcaH genes represent separate reading frames respectively encoding the alpha and beta subunits of protocatechuate 3,4-dioxygenase (EC; previously a single designation, pcaA, had been used to represent DNA encoding this enzyme [4].

Biological context of pcaH

  • Two protocatechuate 3,4-dioxygenase subunits, pcaG and pcaH were detected and identified with N-terminal and internal sequencing, suggesting proteomics using a column separation may be helpful for the identification of specific protein spots and maximizing the detectable protein spots on the 2-DE gel [3].

Analytical, diagnostic and therapeutic context of pcaH


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