Disease relevance of IGKV1D-13

• L18 is a 22-kDa protein that is overexpressed in colorectal cancer tissue [1].
• We examined the effect of intrapleural instillation of MDP-Lys (L18) against malignant pleurisy associated with lung cancer [2].
• Six patients with cytologically-positive malignant pleural effusion (four with adenocarcinoma, one with small cell carcinoma and one with large cell carcinoma) were treated with single intrapleural instillation of MDP-Lys (L18) of 200 microg [2].
• Restorative effect of MDP-Lys (L18) on leukopenia of cancer patient treated with radiotherapy [3].

High impact information on IGKV1D-13

• Analysis of sequence covariation using the entire RNase P RNA data set reveals elements of tertiary structure in the RNA; the third nucleotides (underlined) of the GNRA tetraloops L14 and L18 are seen to interact with adjacent Watson-Crick base pairs in helix P8, forming A:G/C or G:A/U base triples [4].
• Overexpression of L18 may promote protein synthesis and cell growth in certain cancerous tissue through inhibition of PKR activity [1].
• Overexpression of L18 by transient DNA transfection reduced eIF-2alpha phosphorylation and stimulated translation of a reporter gene in vivo [1].
• Muramyl dipeptide (MDP)-Lys (L18), a synthetic MDP analogue derived from bacterial cell walls, has been reported to be a potent immunoadjuvant that enhances protective immunity against pathogens and tumors by stimulating immune-competent cells, such as monocytes and macrophages [5].
• Of the other proteins, S3 and S7 from the small subunit and proteins L6, L18, L19 and L35 from the large subunit were predominantly phosphorylated by the cyclic AMP-dependent enzyme [6].

Chemical compound and disease context of IGKV1D-13

• Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer [2].

Biological context of IGKV1D-13

• We report the nucleotide sequence of human L18 cDNA derived from a normal colon source [7].

Anatomical context of IGKV1D-13

• Ribosomes from H. marismortui, however, released an RNA.protein complex containing a single protein (L18) that is homologous to the single protein found in the eukaryotic 5S ribonucleoprotein complexes [8].

Associations of IGKV1D-13 with chemical compounds

• Furthermore, it was found that omission of veratryl alcohol addition to the culture did not affect the levels of the L18-related transcripts in carbon-limited cultures [9].

Analytical, diagnostic and therapeutic context of IGKV1D-13

• N-terminal sequence analyses of the halophilic 5S RNA-binding proteins suggest that the L18 protein primary structure is highly conserved, with only the H. marismortui protein having a sequence difference in at least the first twenty amino acids [8].

References