Gene Review:
EIF2S1 - eukaryotic translation initiation factor 2...
Homo sapiens
Synonyms:
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, ...
- Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein. Cheng, G., Feng, Z., He, B. J. Virol. (2005)
- The cowpox virus host range gene, CP77, affects phosphorylation of eIF2 alpha and vaccinia viral translation in apoptotic HeLa cells. Hsiao, J.C., Chung, C.S., Drillien, R., Chang, W. Virology (2004)
- Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha. Tinton, S.A., Schepens, B., Bruynooghe, Y., Beyaert, R., Cornelis, S. Biochem. J. (2005)
- Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation. Duncan, R.F., Hershey, J.W. J. Cell Biol. (1989)
- Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Shi, Y., Vattem, K.M., Sood, R., An, J., Liang, J., Stramm, L., Wek, R.C. Mol. Cell. Biol. (1998)
- Impact of virus infection on host cell protein synthesis. Schneider, R.J., Shenk, T. Annu. Rev. Biochem. (1987)
- A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Mazeyrat, S., Saut, N., Grigoriev, V., Mahadevaiah, S.K., Ojarikre, O.A., Rattigan A, n.u.l.l., Bishop, C., Eicher, E.M., Mitchell, M.J., Burgoyne, P.S. Nat. Genet. (2001)
- Protein synthesis persists during necrotic cell death. Saelens, X., Festjens, N., Parthoens, E., Vanoverberghe, I., Kalai, M., van Kuppeveld, F., Vandenabeele, P. J. Cell Biol. (2005)
- RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. Kedersha, N.L., Gupta, M., Li, W., Miller, I., Anderson, P. J. Cell Biol. (1999)
- Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Brush, M.H., Weiser, D.C., Shenolikar, S. Mol. Cell. Biol. (2003)
- Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. Saelens, X., Kalai, M., Vandenabeele, P. J. Biol. Chem. (2001)
- Regulation of translation initiation factor gene expression during human T cell activation. Mao, X., Green, J.M., Safer, B., Lindsten, T., Frederickson, R.M., Miyamoto, S., Sonenberg, N., Thompson, C.B. J. Biol. Chem. (1992)
- Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region. Miyamoto, S., Chiorini, J.A., Urcelay, E., Safer, B. Biochem. J. (1996)
- Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. Donzé, O., Jagus, R., Koromilas, A.E., Hershey, J.W., Sonenberg, N. EMBO J. (1995)
- Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase. Carroll, K., Elroy-Stein, O., Moss, B., Jagus, R. J. Biol. Chem. (1993)
- Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. Satoh, S., Hijikata, M., Handa, H., Shimotohno, K. Biochem. J. (1999)
- Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Obeng, E.A., Carlson, L.M., Gutman, D.M., Harrington, W.J., Lee, K.P., Boise, L.H. Blood (2006)
- The eIF-2alpha kinases and the control of protein synthesis. de Haro, C., Méndez, R., Santoyo, J. FASEB J. (1996)
- Factors from wheat germ that enhance the activity of eukaryotic initiation factor eIF-2. Isolation and characterization of Co-eIF-2 alpha. Osterhout, J.J., Lax, S.R., Ravel, J.M. J. Biol. Chem. (1983)
- Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2. Choi, S.Y., Scherer, B.J., Schnier, J., Davies, M.V., Kaufman, R.J., Hershey, J.W. J. Biol. Chem. (1992)
- Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells. Offermann, M.K., Zimring, J., Mellits, K.H., Hagan, M.K., Shaw, R., Medford, R.M., Mathews, M.B., Goodbourn, S., Jagus, R. Eur. J. Biochem. (1995)
- Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1. Chou, J., Chen, J.J., Gross, M., Roizman, B. Proc. Natl. Acad. Sci. U.S.A. (1995)
- A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells. Wu, S., Rehemtulla, A., Gupta, N.K., Kaufman, R.J. Biochemistry (1996)
- Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. Wang, J., Laschinger, C., Zhao, X.H., Mak, B., Seth, A., McCulloch, C.A. Biochem. Biophys. Res. Commun. (2005)
- Independent signaling of grp78 gene transcription and phosphorylation of eukaryotic initiator factor 2 alpha by the stressed endoplasmic reticulum. Brostrom, M.A., Prostko, C.R., Gmitter, D., Brostrom, C.O. J. Biol. Chem. (1995)
- Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. Arfin, S.M., Kendall, R.L., Hall, L., Weaver, L.H., Stewart, A.E., Matthews, B.W., Bradshaw, R.A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta. Chiorini, J.A., Boal, T.R., Miyamoto, S., Safer, B. J. Biol. Chem. (1993)
- Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. Duncan, R., Hershey, J.W. J. Biol. Chem. (1985)
- Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Rosenwald, I.B., Pechet, L., Han, A., Lu, L., Pihan, G., Woda, B., Chen, J.J., Szymanski, I. Thromb. Haemost. (2001)