The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TRIB2  -  tribbles pseudokinase 2

Homo sapiens

Synonyms: C5FW, GS3955, TRB-2, TRB2, Tribbles homolog 2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TRIB2


High impact information on TRIB2

  • The novel serine/threonine kinase GS3955 was markedly up-regulated (greater than 40-fold) in C4-2, differentially regulated in LNCaP and C4-2 by insulin-like growth factor-1, and variably expressed in human prostate tumor specimens [2].
  • Intrinsic expression of the novel serine/threonine kinase GS3955 in LNCaP, C4-2 and PC-3 prostate cancer cells, and expression when stimulated with growth factors, was monitored by real-time reverse transcriptase-polymerase chain reaction [2].
  • CONCLUSIONS: Differential expression and mitogenic regulation of the serine/threonine kinase GS3955 in LNCaP and C4-2 suggest its functional involvement in the development of androgen independence and/or metastatic potential [2].
  • CONCLUSION: TRB1 and TRB2 genes were not defective in this family [4].

Chemical compound and disease context of TRIB2


  1. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. Zhang, Y., Davis, J.L., Li, W. Mol. Immunol. (2005) [Pubmed]
  2. Expression profiles of androgen independent bone metastatic prostate cancer cells indicate up-regulation of the putative serine-threonine kinase GS3955. Bisoffi, M., Klima, I., Gresko, E., Durfee, P.N., Hines, W.C., Griffith, J.K., Studer, U.E., Thalmann, G.N. J. Urol. (2004) [Pubmed]
  3. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Keeshan, K., He, Y., Wouters, B.J., Shestova, O., Xu, L., Sai, H., Rodriguez, C.G., Maillard, I., Tobias, J.W., Valk, P., Carroll, M., Aster, J.C., Delwel, R., Pear, W.S. Cancer Cell (2006) [Pubmed]
  4. Resistance to thyroid hormone in a family with no TRbeta gene anomaly: pathogenic hypotheses. Vlaeminck-Guillem, V., Margotat, A., Torresani, J., D'herbomez, M., Decoulx, M., Wémeau, J.L. Ann. Endocrinol. (Paris) (2000) [Pubmed]
WikiGenes - Universities