Disease relevance of TRIB1

• No expression of TRIB1 was detected in esophageal squamous cell carcinomas [1].
• The results suggest that C-MYC and TRIB1 may not be the amplification target of 8q24 in esophageal cancer [1].
• Hens reared on ad libitum intake of conventional corn-soybean diets (ad libitum), skip-1-day per week (skip-1-day), and 95% of ad libitum (95%) were placed into cages and photostimulated when they reached a target body weight of 10 kg or at the conventional age of 29 wk [2].
• CONCLUSIONS: Skip metastasis are frequent in non-small-cell lung cancer and complete dissection of hilar and mediastinal lymph nodes should remain the surgical standard procedure for this disease [3].

High impact information on TRIB1

• The TRIB1 gene was found over-expressed in only a subset of the AML/MDS cases, whereas MYC, contrary to expectations, was always silent [4].
• TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance [5].
• The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy [5].
• We identified type II keratin 5, lamin A, the cytoplasmic domain of integrin beta4 subunit and a phosphoprotein C8FW as 12-LOX interacting proteins [6].
• CONCLUSION: TRB1 and TRB2 genes were not defective in this family [7].

Biological context of TRIB1

• Parallel analysis of gene expression in critical amplicons displayed overexpressed candidate genes (eg, C8FW and MYC in 8q24) [8].
• METHODS: Infants with GORD (defined by 24-h pH monitoring, n = 20), and age, gender, gestation, and socio-economic matched healthy infants (n = 20) had standardised assessments of dietary intake, oromotor function by videoanalysis (Feeding Assessment Schedule, FAS), and infant feeding behaviour by Testers and Maternal Ratings (TRIB and MRIB) [9].

Analytical, diagnostic and therapeutic context of TRIB1

• Expression status of the TRIB1 and MYC genes, encompassed by the minimally amplified region, was assessed by northern blot analysis [4].

References