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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Corin  -  corin, serine peptidase

Rattus norvegicus

Synonyms: Atrial natriuretic peptide-converting enzyme, Pro-ANP-converting enzyme
 
 
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High impact information on Corin

  • In a rat model of heart failure induced by ligation of the left coronary artery, corin mRNA expression in the noninfarcted LV myocardium was significantly higher than that of control heart tissues from sham-operated animals, when examined by Northern blot analysis and RT-PCR at 8 wk [1].
  • Quantitative RT-PCR analysis showed that both corin and ANP mRNA levels were significantly increased in phenylephrine (PE)-stimulated rat neonatal cardiomyocytes in culture [1].
  • In this study, we examined the regulation of corin gene expression in cultured hypertrophic cardiomyocytes and in the left ventricular (LV) myocardium of a rat model of heart failure [1].
  • Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium [1].
  • The increase in corin mRNA correlated closely with the increase in cell size and ANP mRNA expression in the PE-treated cells (r = 0.95, P < 0.01; r = 0.92, P < 0.01, respectively) [1].
 

Anatomical context of Corin

  • These results indicate that the corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium [1].
 

Analytical, diagnostic and therapeutic context of Corin

References

  1. Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. Tran, K.L., Lu, X., Lei, M., Feng, Q., Wu, Q. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  2. Rat corin gene: molecular cloning and reduced expression in experimental heart failure. Langenickel, T.H., Pagel, I., Buttgereit, J., Tenner, K., Lindner, M., Dietz, R., Willenbrock, R., Bader, M. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
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