Disease relevance of CORIN

• The demonstrated corin protein expression by heart myocytes supports its proposed role as the pro-ANP convertase, and thus a potentially critical mediator of major cardiovascular diseases including hypertension and congestive heart failure [1].
• Corin-mediated processing of pro-atrial natriuretic peptide in human small cell lung cancer cells [2].
• The independent association of the minor corin allele with increased risk for prevalent hypertension was confirmed in the Multi-Ethnic Study of Atherosclerosis (odds ratio, 1.50; 95% CI, 1.09 to 2.06; P=0.014) [3].
• Targeted and naturally occurring mutations in the murine Megf7/Lrp4 gene, a putative coreceptor in the Wnt signaling pathway, cause polysyndactyly in the rodent [4].
• It is suggested that GSA might be a more sensitive marker for renal dysfunction than SUN at the end stage of chronic renal failure, and MG/CRN might represent another indicator reflecting the activity of the causal renal disease and progression rate of renal failure [5].

High impact information on CORIN

• In this study, we examine effects of corin on pro-ANP processing [6].
• Recently, we cloned a transmembrane serine protease, corin, that is highly expressed in the heart [6].
• Transfection of small interfering RNA duplexes directed against the corin gene completely blocked the processing of pro-ANP in the SCLC cells [2].
• We also suggest that the expression of corin may contribute to the pathogenesis of the syndrome of inappropriate secretion of antidiuretic hormone associated with certain cancers [2].
• We also made corin mutants with a single mutation at a conserved Asp residue that coordinates Ca(2+)-binding in LDLR repeats 1, 2, 3, or 4 (D300Y, D336Y, D373Y, and D410Y) and showed that these mutants had approximately 25, approximately 11, approximately 16, and approximately 82% pro-ANP processing activity, respectively [7].

Biological context of CORIN

• In in vitro experiments, recombinant human corin has recently been shown to activate pro-atrial natriuretic peptide (ANP), a cardiac hormone essential for the regulation of blood pressure [1].
• Sequencing of the human corin gene identified 2 nonsynonymous, nonconservative single nucleotide polymorphisms (Q568P and T555I) in near-complete linkage disequilibrium, thus describing a single minor I555 (P568) corin gene allele [3].
• Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension [3].
• In addition, the association of the minor corin I555 (P568) allele with higher systolic blood pressure was confirmed in adjusted analysis in the Chicago Genetics of Hypertension Study (125.8+/-1.9 versus 121.4+/-0.7 mm Hg; P=0.03) [3].

Anatomical context of CORIN

• Localization of the mosaic transmembrane serine protease corin to heart myocytes [1].
• Corin was not detected in sections of skeletal or smooth muscle [1].
• Immunostaining of sections of human heart showed corin expression was specifically localized to the cross striations of cardiac myocytes, with a pattern of expression consistent with an integral membrane localization [1].
• Reverse transcription-PCR detected corin mRNA expression in all nine SCLC cell lines examined and ANP mRNA expression in seven of the nine cell lines [2].
• One selected mAb (ATC2) showed specific staining on germ cell tumours but not on normal tissues, and positive staining with some human tumour cell lines [8].

Associations of CORIN with chemical compounds

• In cell-based studies, corin converted pro-atrial natriuretic peptide (pro-ANP) to mature ANP, suggesting that corin is potentially the pro-ANP convertase [9].
• The disappearance of i.v. injected 99mTc-DTPA (Sn) was also recorded from the body surface by means of a low weight cadmium telluride detector (CRN, Strasbourg, France) and commercially available stationary or portable tape recorders [10].
• MG/CRN showed a negative correlation with the progression rate of renal dysfunction (P less than 0.01) [5].
• Maureen Moriarty-Sheehan, MS, CRNP, who also served as chairperson, presented the third topic, "Developing a Management Plan for Optimal Patient Benefit."[11]
• The ratio of methylguanidine to creatinine (MG/CRN) was significantly higher in the patients of group B than those of group A (P less than 0.05) in the range of creatinine 2.0-8.0 mg/dl [5].

Other interactions of CORIN

• Corin cDNA encodes an unusual mosaic type II transmembrane serine protease, which possesses, in addition to a trypsin-like serine protease domain, two frizzled domains, eight low-density lipoprotein (LDL) receptor domains, a scavenger receptor domain, as well as an intracellular cytoplasmic domain [1].
• However examination of corin protein expression in TAPVR heart tissue did not show evidence of abnormal corin expression [1].
• These data highlight the novel observation that scar myofibroblasts synthesized ANP, BNP, adrenomedullin, and expressed the pro-convertase corin [12].
• These results allowed us to design, express, and purify a mutant soluble corin, EKsolCorin, that contains an enterokinase recognition sequence at the activation cleavage site [9].
• Although MFRP was homologous to Corin, FZDs, and SFRPs in CRD, amino-acid identities between CRD in MFRP and CRDs in these molecules were less than 40% [13].

Analytical, diagnostic and therapeutic context of CORIN

• A review of 184 patients (193 knees) who underwent placement of a Rotaglide (Corin, Cirencester, UK) posterior-stabilized prosthesis with patellar resurfacing showed that only 33 knees (17%) had complete absence of femoropatellar complaints after at least 1 year of follow-up evaluation [14].
• Of 21 patients, 6 of 10 who progressed to CRN and 2 of 11 who did not had a positive Adnab-9 ELISA result (P=0.08) [15].
• This study measures the serum cobalt and chromium levels in patients with an Oxford Universal Hip (Corin, Cirencester, United Kingdom), which has a modular sliding mechanism; patients with a similarly manufactured hip with no sliding mechanism; and a control group [16].
• Thus ATC2 may be useful for monitoring serum levels of PLAP in patients with testis cancer and may be relevant for detecting cancer cells in the semen of individuals with suspected testis cancer, particularly in those with equivocal findings on ultrasonography [8].
• Four versions of a certain femoral hip prosthesis (the Freeman, Corin Medical), cemented, HA coated, press-fit, and press-fit with ridges were analysed [17].

References