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Gene Review

KLF15  -  Kruppel-like factor 15

Homo sapiens

Synonyms: KKLF, Kidney-enriched krueppel-like factor, Krueppel-like factor 15
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High impact information on KLF15


Biological context of KLF15

  • Based on the known expression pattern of KLF15 in non-photoreceptor cells, we hypothesize an in vivo role for KLF15 in repressing photoreceptor-specific gene expression in the inner retina [4].
  • Both the bovine rhodopsin and IRBP promoters contained multiple KLF15 binding sites that included the previously identified CRS-1 and G-rich repressor elements [4].

Anatomical context of KLF15

  • Quantification of various KLF transcripts revealed that 48 h fasting robustly induced the KLF15 transcripts in the skeletal muscle [5].

Analytical, diagnostic and therapeutic context of KLF15

  • Expression studies used RT-PCR and beta-galactosidase (LacZ) histochemistry of retinas from transgenic mice heterozygous for a targeted LacZ replacement of KLF15 [6].


  1. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor. Uchida, S., Tanaka, Y., Ito, H., Saitoh-Ohara, F., Inazawa, J., Yokoyama, K.K., Sasaki, S., Marumo, F. Mol. Cell. Biol. (2000) [Pubmed]
  2. The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. Banerjee, S.S., Feinberg, M.W., Watanabe, M., Gray, S., Haspel, R.L., Denkinger, D.J., Kawahara, R., Hauner, H., Jain, M.K. J. Biol. Chem. (2003) [Pubmed]
  3. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Suda, S., Rai, T., Sohara, E., Sasaki, S., Uchida, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. Otteson, D.C., Lai, H., Liu, Y., Zack, D.J. BMC Mol. Biol. (2005) [Pubmed]
  5. A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. Yamamoto, J., Ikeda, Y., Iguchi, H., Fujino, T., Tanaka, T., Asaba, H., Iwasaki, S., Ioka, R.X., Kaneko, I.W., Magoori, K., Takahashi, S., Mori, T., Sakaue, H., Kodama, T., Yanagisawa, M., Yamamoto, T.T., Ito, S., Sakai, J. J. Biol. Chem. (2004) [Pubmed]
  6. Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters. Otteson, D.C., Liu, Y., Lai, H., Wang, C., Gray, S., Jain, M.K., Zack, D.J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
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