Disease relevance of LOC290741

• It is concluded that the Dunning hepatoma probably has intrinsically low deoxycytidylate deaminase activity [1].

High impact information on LOC290741

• Factors which might affect the activity of deoxycytidylate deaminase in the Dunning hepatoma have been examined in it and compared to the Novikoff hepatoma which has high activity of this enzyme [1].
• This effect appeared to be the result of a decrease, caused by 6-thioguanine, in the induction of several enzyme activities (i.e., thymidine kinase, deoxycytidylate deaminase, cytidine diphosphate reductase, and DNA polymerase) necessary for the initiation of DNA replication in regenerating liver [2].
• Correlation of deoxycytidylate deaminase activity with cell proliferation during hepatocarcinogenesis and tumour growth in transplantable rat hepatomas [3].
• Proliferative activity of liver cells was simultaneously followed by deoxycytidylate deaminase [4].

Chemical compound and disease context of LOC290741

• Determination of activity of deoxycytidylate deaminase stabilized by etylene glycol was used to evaluate the rate of DNA synthesis in precancerous liver tissue and in transplantable rat hepatomas [3].

Biological context of LOC290741

• Liver regeneration is represented by the ornithin decarboxylase, the deoxycytidylate deaminase, the thymidine kinase activities and the hepatic putrescine content [5].

References