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Gene Review

DCTD  -  dCMP deaminase

Homo sapiens

Synonyms: Deoxycytidylate deaminase
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Disease relevance of DCTD


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Chemical compound and disease context of DCTD


Biological context of DCTD


Anatomical context of DCTD


Associations of DCTD with chemical compounds


Other interactions of DCTD


Analytical, diagnostic and therapeutic context of DCTD


  1. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. Weiner, K.X., Weiner, R.S., Maley, F., Maley, G.F. J. Biol. Chem. (1993) [Pubmed]
  2. Deoxycytidylate deaminase activity in non-stimulated and phytohemagglutinin-stimulated human lymphocytes, and in leukemic cells. Tyrsted, G., Chao, P.C., Munch-Petersen, B. Mol. Cell. Biochem. (1987) [Pubmed]
  3. T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit. Moore, J.T., Silversmith, R.E., Maley, G.F., Maley, F. J. Biol. Chem. (1993) [Pubmed]
  4. Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase. Liou, J.Y., Krishnan, P., Hsieh, C.C., Dutschman, G.E., Cheng, Y.C. Mol. Pharmacol. (2003) [Pubmed]
  5. Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells. Gribaudo, G., Riera, L., Caposio, P., Maley, F., Landolfo, S. J. Gen. Virol. (2003) [Pubmed]
  6. Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma. Wiley, J.S., Taupin, J., Jamieson, G.P., Snook, M., Sawyer, W.H., Finch, L.R. J. Clin. Invest. (1985) [Pubmed]
  7. A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase. Maley, F., Maley, G.F. Prog. Nucleic Acid Res. Mol. Biol. (1990) [Pubmed]
  8. Regulation of pyrimidine deoxyribonucleotide metabolism by substrate cycles in dCMP deaminase-deficient V79 hamster cells. Bianchi, V., Pontis, E., Reichard, P. Mol. Cell. Biol. (1987) [Pubmed]
  9. Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation. Heinemann, V., Xu, Y.Z., Chubb, S., Sen, A., Hertel, L.W., Grindey, G.B., Plunkett, W. Cancer Res. (1992) [Pubmed]
  10. A T4-phage deoxycytidylate deaminase mutant that no longer requires deoxycytidine 5'-triphosphate for activation. Keefe, R.G., Maley, G.F., Saxl, R.L., Maley, F. J. Biol. Chem. (2000) [Pubmed]
  11. Plasma urate and serum deoxycytidylate deaminase measurements for the early diagnosis of pre-eclampsia. Redman, C.W., Williams, G.F., Jones, D.D., Wilkinson, R.H. British journal of obstetrics and gynaecology. (1977) [Pubmed]
  12. Serum deoxycytidylate deaminase activity after myocardial infarction. Roberts, R.G., Davies, A.G., Jones, D.D. Ann. Clin. Biochem. (1978) [Pubmed]
  13. Deoxycytidylate deaminase in the diagnosis of acute myocardial infarction. Georgiades, C., Cokkinos, D.V., Kalofoutis, A., Miras, C. Acta cardiologica. (1985) [Pubmed]
  14. Pyrimidine nucleotide metabolism in L5178Y murine leukemia cells: deoxycytidine protection from deoxyguanosine toxicity. Theiss, J.C., Morris, N.R., Fischer, G.A. Cancer Biochem. Biophys. (1976) [Pubmed]
  15. Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics. Gilbert, J.A., Salavaggione, O.E., Ji, Y., Pelleymounter, L.L., Eckloff, B.W., Wieben, E.D., Ames, M.M., Weinshilboum, R.M. Clin. Cancer Res. (2006) [Pubmed]
  16. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. Weiner, K.X., Ciesla, J., Jaffe, A.B., Ketring, R., Maley, F., Maley, G.F. J. Biol. Chem. (1995) [Pubmed]
  17. Sensitization to X ray by 5-chloro-2'-deoxycytidine co-administered with tetrahydrouridine in several mammalian cell lines and studies of 2'-chloro derivatives. Perez, L.M., Greer, S. Int. J. Radiat. Oncol. Biol. Phys. (1986) [Pubmed]
  18. Effect of cell growth and cell differentiation on 1-beta-D-arabinofuranosylcytosine metabolism in myeloid cells. Chiba, P., Tihan, T., Eher, R., Köller, U., Wallner, C., Göbl, R., Linkesch, W. Br. J. Haematol. (1989) [Pubmed]
  19. Degradation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in human leukemic myeloblasts and lymphoblasts. Jamieson, G.P., Finch, L.R., Snook, M., Wiley, J.S. Cancer Res. (1987) [Pubmed]
  20. Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells. Kaysen, J., Spriggs, D., Kufe, D. Cancer Res. (1986) [Pubmed]
  21. Effect of 5-fluoro-2'-deoxyuridine and hydroxyurea on the phytohemagglutinin-induced increase of thymidine kinase, replicative DNA polymerase, deoxycytidylate deaminase and CDP reductase activities in human lymphocytes. Tyrsted, G. Mol. Cell. Biochem. (1984) [Pubmed]
  22. Allosteric transitions associated with the binding of substrate and effector ligands to T2 phage induced deoxycytidylate deaminase. Maley, G.F., Maley, F. Biochemistry (1982) [Pubmed]
  23. 5-Methyldeoxycytidine monophosphate deaminase and 5-methylcytidyl-DNA deaminase activities are present in human mature sperm cells. Jost, J.P., Thiry, S., Siegmann, M. FEBS Lett. (2002) [Pubmed]
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