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Gene Review:

C6orf15 - chromosome 6 open reading frame 15

Homo sapiens

Synonyms: Protein STG, STG, UNQ1840/PRO3566, Uncharacterized protein C6orf15

Kimura, N. et al., Sánchez, F. et al., Neira, M. et al., Chen, M.Y. et al.

Sánchez, Holm, Mallbris, O'Brien, Ståhle, Neira, Danilova, Hellekant, Azen,

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Disease relevance of C6orf15

STG does not associate with psoriasis in the Swedish population [1].

High impact information on C6orf15

RT-PCR results showed a significant level of STG II expression in haemocytes but not in hepatopancreas, in contrast to shrimp STG I (AY074924.1) [2].
STG expression was investigated in human tissues and found not to be restricted to taste buds, with signals also being detected in skin and tonsils [1].
The monkey, human, and mouse STG proteins contain potential O-glycosylation sites and tandem repeats inside a region showing approximately 50% similarity with prion proteins [3].
Mast cells expressed STG I in various states [4].
STG I may mediate exocytosis of large granules in mast cells [4].

Biological context of C6orf15

None of these STG single-nucleotide polymorphisms were found to be significantly associated with psoriasis [1].

Anatomical context of C6orf15

STG I mRNA was detected in both non-stimulated and stimulated HMC-1 cells and in NB-1 and PC12 cells [4].
Synaptotagmin I (STG I) is a Ca(2+) sensor and one of the synaptic vesicle proteins that mediate exocytosis [4].

Analytical, diagnostic and therapeutic context of C6orf15

STG I mRNA and its products in HMC-1 were examined by RT-PCR analysis and immunocytochemistry, respectively [4].

References

STG does not associate with psoriasis in the Swedish population. Sánchez, F., Holm, S.J., Mallbris, L., O'Brien, K.P., Ståhle, M. Exp. Dermatol. (2004) [Pubmed]
More than one type of transglutaminase in invertebrates? A second type of transglutaminase is involved in shrimp coagulation. Chen, M.Y., Hu, K.Y., Huang, C.C., Song, Y.L. Dev. Comp. Immunol. (2005) [Pubmed]
A new gene (rmSTG) specific for taste buds is found by laser capture microdissection. Neira, M., Danilova, V., Hellekant, G., Azen, E.A. Mamm. Genome (2001) [Pubmed]
Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line. Kimura, N., Shiraishi , S., Mizunashi, K., Ohtsu, H., Kimura, I. J. Histochem. Cytochem. (2001) [Pubmed]

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C23H6orf15	Bos taurus
C12H6orf15	Canis lupus familiaris
C4H6orf15	Macaca mulatta
2300002M23Rik	Mus musculus
C6H6orf15	Pan troglodytes
RGD1562885	Rattus norvegicus

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