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Npy1r  -  neuropeptide Y receptor Y1

Rattus norvegicus

Synonyms: FC5, NPY1-R, Neuropeptide Y receptor type 1
 
 
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High impact information on Npy1r

  • 5. We conclude that NPY1 and NPY2 receptors are functionally segregated in the thalamus: NPY1 receptors are predominantly expressed at the somata and dendrites and directly reduce the excitability of neurons in both the RT and VB nuclei by activating GIRK channels [1].
  • 4. NPY activation of GIRK channels was mediated via NPY1 receptors, whereas inhibition of N- and P/Q-type Ca2+ channels was mediated by NPY2 receptors [2].
  • In the present work, we investigated the role of pre- and post-synaptic neuropeptide Y1 (NPY1) and Y2 receptors on the calcium responses and on glutamate release in the rat hippocampus [3].
  • The present data support a predominant role for NPY2 receptors in mediating NPY-induced inhibition of glutamate release in the hippocampus, but the physiological relevance of the presently described DG and CA3 pre-synaptic NPY1 receptors remains to be clarified [3].
  • However, studies with hippocampal synaptosomes showed that both NPY1 and Y2 receptors can modulate the [Ca(2+)](i) and glutamate release [3].
 

Biological context of Npy1r

  • 6. We conclude that nerve-mediated vasoconstriction results from the activation of postsynaptic alpha,beta-adrenergic and P2X-purinergic receptors and under some conditions, NPY1 receptors [4].
  • In Exp. 1, the i.c.v. injection of NPY into intact rats stimulated food intake compared with the injection of saline 1 and 3 h after the injections in a dose dependent manner (1 h; NPY 1 microgram, 3.29 +/- 0.43, 2 micrograms, 4.64 +/- 0.88, 5 micrograms, 5.15 +/- 0.61 vs. saline 2.48 +/- 0.42 g, P < 0.05 in 2 and 5 micrograms) [5].
 

Anatomical context of Npy1r

 

Associations of Npy1r with chemical compounds

  • 5. Some experiments demonstrated a slow neurogenic contraction which was abolished by GE or the selective NPY1 receptor antagonist 1229U91 (6 x 10(-7) M) [4].

References

  1. Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. Sun, Q.Q., Akk, G., Huguenard, J.R., Prince, D.A. J. Physiol. (Lond.) (2001) [Pubmed]
  2. Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons. Sun, Q.Q., Huguenard, J.R., Prince, D.A. J. Physiol. (Lond.) (2001) [Pubmed]
  3. Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus. Silva, A.P., Carvalho, A.P., Carvalho, C.M., Malva, J.O. J. Neurochem. (2001) [Pubmed]
  4. Receptors involved in nerve-mediated vasoconstriction in small arteries of the rat hepatic mesentery. Phillips, J.K., McLean, A.J., Hill, C.E. Br. J. Pharmacol. (1998) [Pubmed]
  5. Effects of intraventricular administration of neuropeptide Y on feeding behavior in fasted female rats with ventromedial hypothalamic lesions. Tanaka, Y., Egawa, M., Inoue, S., Takamura, Y. Regul. Pept. (1994) [Pubmed]
  6. Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats. Tebbe, J.J., Tebbe, C.G., Mronga, S., Ritter, M., Schäfer, M.K. BMC gastroenterology [electronic resource]. (2005) [Pubmed]
  7. Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus. Madsen, T.M., Greisen, M.H., Nielsen, S.M., Bolwig, T.G., Mikkelsen, J.D. Neuroscience (2000) [Pubmed]
  8. Agonists for neuropeptide Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents. Wiley, J.W., Gross, R.A., MacDonald, R.L. J. Neurophysiol. (1993) [Pubmed]
 
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