The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Npy1r  -  neuropeptide Y receptor Y1

Mus musculus

Synonyms: NPY1-R, Neuropeptide Y receptor type 1, Npyr, Y1-R
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Npy1r


Psychiatry related information on Npy1r


High impact information on Npy1r


Chemical compound and disease context of Npy1r


Biological context of Npy1r


Anatomical context of Npy1r


Associations of Npy1r with chemical compounds

  • Double staining revealed co-existence of Y1R-like immunoreactivity and immunoreactivities for thyrotropin-releasing hormone (TRH) and, to a minor extent, cocaine- and amphetamine-regulated transcript peptide in parvocellular neurons [16].
  • The lack of effects with GR231118 and the nonstereoselective effects of BIBP3226 suggested that NPY-induced feeding in mice was not mediated via the Y1 receptor [18].
  • Furthermore, we demonstrated that a sustained increase in the brain concentrations of neuroactive steroids, induced by pharmacological treatment or by physiological conditions such as pregnancy, increases Y1 receptor gene expression in the amygdala of Y1R/LacZ transgenic mice, an effect similar to that induced by diazepam or abecarnil [19].
  • We tested the hypothesis that E2 up-regulates NPY's actions by stimulating NPY Y1 receptor (Y1r) gene expression through a mechanism mediated by E2's ability to induce progesterone (P) receptors (PRs) [20].
  • 3. The Y1 receptor antagonist BIBO3304 blocked responses to the Y1 agonist at the lower doses, but only partially inhibited at the higher doses tested in Y2+/+ [21].

Physical interactions of Npy1r


Regulatory relationships of Npy1r


Other interactions of Npy1r


Analytical, diagnostic and therapeutic context of Npy1r


  1. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Kushi, A., Sasai, H., Koizumi, H., Takeda, N., Yokoyama, M., Nakamura, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Naveilhan, P., Hassani, H., Lucas, G., Blakeman, K.H., Hao, J.X., Xu, X.J., Wiesenfeld-Hallin, Z., Thorén, P., Ernfors, P. Nature (2001) [Pubmed]
  3. Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. Tovote, P., Meyer, M., Beck-Sickinger, A.G., von Hörsten, S., Ove Ogren, S., Spiess, J., Stiedl, O. Regul. Pept. (2004) [Pubmed]
  4. Regulation of mouse neuropeptide Y Y1 receptor gene transcription: a potential role for nuclear factor-kappa B/Rel proteins. Musso, R., Grilli, M., Oberto, A., Gamalero, S.R., Eva, C. Mol. Pharmacol. (1997) [Pubmed]
  5. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Kanatani, A., Hata, M., Mashiko, S., Ishihara, A., Okamoto, O., Haga, Y., Ohe, T., Kanno, T., Murai, N., Ishii, Y., Fukuroda, T., Fukami, T., Ihara, M. Mol. Pharmacol. (2001) [Pubmed]
  6. Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety. Karl, T., Burne, T.H., Herzog, H. Behav. Brain Res. (2006) [Pubmed]
  7. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Pedrazzini, T., Seydoux, J., Künstner, P., Aubert, J.F., Grouzmann, E., Beermann, F., Brunner, H.R. Nat. Med. (1998) [Pubmed]
  8. A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. Wheway, J., Mackay, C.R., Newton, R.A., Sainsbury, A., Boey, D., Herzog, H., Mackay, F. J. Exp. Med. (2005) [Pubmed]
  9. Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. Lee, E.W., Michalkiewicz, M., Kitlinska, J., Kalezic, I., Switalska, H., Yoo, P., Sangkharat, A., Ji, H., Li, L., Michalkiewicz, T., Ljubisavljevic, M., Johansson, H., Grant, D.S., Zukowska, Z. J. Clin. Invest. (2003) [Pubmed]
  10. Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice. Sainsbury, A., Bergen, H.T., Boey, D., Bamming, D., Cooney, G.J., Lin, S., Couzens, M., Stroth, N., Lee, N.J., Lindner, D., Singewald, N., Karl, T., Duffy, L., Enriquez, R., Slack, K., Sperk, G., Herzog, H. Diabetes (2006) [Pubmed]
  11. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Kask, A., Rägo, L., Korrovits, P., Wikberg, J.E., Schiöth, H.B. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  12. Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8. Lutz, C.M., Frankel, W.N., Richards, J.E., Thompson, D.A. Genomics (1997) [Pubmed]
  13. Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor. Nakamura, M., Yokoyama, M., Watanabe, H., Matsumoto, T. Biochim. Biophys. Acta (1997) [Pubmed]
  14. Evidence of altered neuropeptide Y content and neuropeptide Y1 receptor gene expression in the hypothalamus of pregnant transgenic mice. Oberto, A., Mele, P., Zammaretti, F., Panzica, G., Eva, C. Endocrinology (2003) [Pubmed]
  15. Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. Howell, O.W., Doyle, K., Goodman, J.H., Scharfman, H.E., Herzog, H., Pringle, A., Beck-Sickinger, A.G., Gray, W.P. J. Neurochem. (2005) [Pubmed]
  16. Neuropeptide Y innervation and neuropeptide-Y-Y1-receptor-expressing neurons in the paraventricular hypothalamic nucleus of the mouse. Broberger, C., Visser, T.J., Kuhar, M.J., Hökfelt, T. Neuroendocrinology (1999) [Pubmed]
  17. Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. Kishi, T., Aschkenasi, C.J., Choi, B.J., Lopez, M.E., Lee, C.E., Liu, H., Hollenberg, A.N., Friedman, J.M., Elmquist, J.K. J. Comp. Neurol. (2005) [Pubmed]
  18. Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding? Iyengar, S., Li, D.L., Simmons, R.M. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  19. Neuroanatomical and pharmacological evidence for a functional interaction between GABAergic and NPY-Y1 transmission in the amygdala of Y1R/LacZ transgenic mice. Eva, C., Mele, P., Oberto, A., Panzica, G., Pisu, M.G., Serra, M. Critical reviews in neurobiology. (2004) [Pubmed]
  20. Regulation of hypothalamic neuropeptide Y Y1 receptor gene expression during the estrous cycle: role of progesterone receptors. Xu, M., Urban, J.H., Hill, J.W., Levine, J.E. Endocrinology (2000) [Pubmed]
  21. The ability of neuropeptide Y to mediate responses in the murine cutaneous microvasculature: an analysis of the contribution of Y1 and Y2 receptors. Chu, D.Q., Cox, H.M., Costa, S.K., Herzog, H., Brain, S.D. Br. J. Pharmacol. (2003) [Pubmed]
  22. Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Raposinho, P.D., Pedrazzini, T., White, R.B., Palmiter, R.D., Aubert, M.L. Endocrinology (2004) [Pubmed]
  23. Studies on neuropeptide Y receptors in a mouse adrenocortical cell line. Weng, G., Yee, F., Michl, P., Reis, D., Wahlestedt, C. Mol. Pharmacol. (1995) [Pubmed]
  24. Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers. Shi, T.J., Li, J., Dahlström, A., Theodorsson, E., Ceccatelli, S., Decosterd, I., Pedrazzini, T., Hökfelt, T. Neuroscience (2006) [Pubmed]
  25. The murine Y1 receptor 5' upstream sequence directs cell-specific and developmentally regulated LacZ expression in transgenic mice CNS. Oberto, A., Tolosano, E., Brusa, R., Altruda, F., Panzica, G., Eva, C. Eur. J. Neurosci. (1998) [Pubmed]
WikiGenes - Universities