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Gene Review

Cxcr5  -  chemokine (C-X-C motif) receptor 5

Rattus norvegicus

Synonyms: Blr1, Burkitt lymphoma receptor 1 homolog, C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, ...
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Psychiatry related information on Blr1

  • After finding that DOI was able to attenuate the percentage nicotine lever responding (%NLR), we tested for it to also reverse nicotine's effects on locomotor activity in mice [1].

High impact information on Blr1

  • MK 212 and 8-OH-DPAT had irregular effects among rats and only reduced %NLR to below 50% levels at doses markedly suppressing responding [1].
  • This distribution suggests a role of NLR in the nervous and immune systems [2].
  • Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue [2].
  • Northern blot analysis of NLR revealed a predominant 5.5 kb mRNA species in various brain regions and neuronal cell lines, whereas in the spleen a 3 kb transcript is predominant [2].
  • The aim of this study was to investigate bile acid (BA) secretion into bile during normal (NLR) and synchronized (SLR) liver regeneration in rats [3].

Associations of Blr1 with chemical compounds

  • Most BA molecules were conjugated with taurine rather than with glycine in all experimental groups, during both NLR and SLR [3].
  • Changes in the proportion of secreted BA species were similar in SLR and NLR except that the early reduction in the proportion of BAs other than cholic acid was more pronounced in SLR and the quantitative importance of the diversity in BA species was recovered earlier in SLR than in NLR [3].

Analytical, diagnostic and therapeutic context of Blr1

  • Amidated BA output as measured by HPLC analysis revealed an early enhancement in the proportion of non-conjugated BAs in bile in NLR [3].


  1. Attenuation of nicotine's discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonists. Batman, A.M., Munzar, P., Beardsley, P.M. Psychopharmacology (Berl.) (2005) [Pubmed]
  2. Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue. Kouba, M., Vanetti, M., Wang, X., Schäfer, M., Höllt, V. FEBS Lett. (1993) [Pubmed]
  3. Bile acid secretion during synchronized rat liver regeneration. Monte, M.J., El-Mir, M.Y., Sainz, G.R., Bravo, P., Marin, J.J. Biochim. Biophys. Acta (1997) [Pubmed]
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