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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CeHV15ggp350  -  gp350

Macacine herpesvirus 4

 
 
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Disease relevance of CeHV15ggp350

  • As an initial application, a live recombinant VZV expressing Epstein-Barr virus (EBV) membrane glycoproteins (gp350/220) was generated by inserting a gene fusion of the VZV gpI promoter and hydrophobic leader-encoding sequence with the gp350/220 coding sequence into the thymidine kinase (TK) gene of VZV (Oka) [1].
  • The results suggest that gp350 may be effective as an immunogen to prevent EBV-associated infectious mononucleosis in humans that are EBV-seronegative [2].
 

High impact information on CeHV15ggp350

  • RNA splicing, glycosylation, and plasma membrane presentation of gp350/220 in cells infected with the recombinant virus were similar to those seen in EBV-infected cells [1].
  • The human gammaherpesviruses Epstein-Barr virus and Kaposi Sarcoma-associated herpesvirus both contain a glycoprotein (gp350/220 and K8.1, respectively) that mediates binding to target cells and has been studied in great detail in vitro [3].
  • In these experiments we were able to demonstrate the feasibility of our approach for the investigation of EBV-specific ADCC reactions and could confirm the role of gp 350/220 as an ADCC target [4].
  • The resulting transformed 'integrant' cells produced approximately five-fold more gp350 mRNA and ten-fold more gp350-related proteins than the transformed 'non-integrant' cells following galactose induction [5].
 

Biological context of CeHV15ggp350

  • Recently, the viral membrane protein gp 350/220, which is also expressed at the surface of the virus producing cell, was identified as a target for ADCC reactions [4].

References

  1. Varicella-zoster virus as a live vector for the expression of foreign genes. Lowe, R.S., Keller, P.M., Keech, B.J., Davison, A.J., Whang, Y., Morgan, A.J., Kieff, E., Ellis, R.W. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Murine gamma-herpesvirus 68 glycoprotein 150 protects against virus-induced mononucleosis: a model system for gamma-herpesvirus vaccination. Stewart, J.P., Micali, N., Usherwood, E.J., Bonina, L., Nash, A.A. Vaccine (1999) [Pubmed]
  3. In vivo function of a gammaherpesvirus virion glycoprotein: influence on B-cell infection and mononucleosis. Stewart, J.P., Silvia, O.J., Atkin, I.M., Hughes, D.J., Ebrahimi, B., Adler, H. J. Virol. (2004) [Pubmed]
  4. The Epstein-Barr virus-encoded glycoprotein gp 110 (BALF 4) can serve as a target for antibody-dependent cell-mediated cytotoxicity (ADCC). Jilg, W., Bogedain, C., Mairhofer, H., Gu, S.Y., Wolf, H. Virology (1994) [Pubmed]
  5. Regulated overproduction of the GAL4 gene product greatly increases expression from galactose-inducible promoters on multi-copy expression vectors in yeast. Schultz, L.D., Hofmann, K.J., Mylin, L.M., Montgomery, D.L., Ellis, R.W., Hopper, J.E. Gene (1987) [Pubmed]
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