Disease relevance of Infectious Mononucleosis

• In sera from patients with acute EBV, infection and the clinical symptoms of infectious mononucleosis antibodies of the Ig class M were found that are directed against two cellular proteins [1].
• Autoantibodies against triosephosphate isomerase. A possible clue to pathogenesis of hemolytic anemia in infectious mononucleosis [1].
• Possibly, anti-TPI causes hemolysis, which is an infrequent but serious symptom of infectious mononucleosis [1].
• The intracellular Epstein-Barr virus (EBV) DNA present in virus-transformed cells was partly purified from 23 cell lines or biopsies of Burkitt lymphoma, nasopharyngeal carcinoma, infectious mononucleosis, or healthy carrier origin [2].
• Further functional studies of the SH2D1A protein will probably provide new insights into the pathogenesis of severe infectious mononucleosis, malignant lymphomas and immunodeficiency in patients with XLP [3].

High impact information on Infectious Mononucleosis

• Inappropriate antidiuretic hormone secretion with infectious mononucleosis [4].
• Increased clearance of phenytoin during infectious mononucleosis [5].
• Mitotic EBNA-positive lymphocytes in peripheral blood during infectious mononucleosis [6].
• Antibodies directed against the autoantigen p26 were detected in sera from 32 patients with acute Epstein-Barr virus (EBV) infection and clinical symptoms of infectious mononucleosis [7].
• Hematopoietic and lymphatic cancers in relatives of patients with infectious mononucleosis [8].

Chemical compound and disease context of Infectious Mononucleosis

• During infectious mononucleosis, IgM autoantibodies are generated to a protein, p542, which contains a glycine-rich 28-mer epitope cross-reactive with the Epstein-Barr nuclear antigen-1 through Epstein-Barr nuclear antigen-1's glycine/alanine repeat [9].
• Letter: Infectious-mononucleosis rash after talampicillin [10].
• Autoimmunity to cardiolipin in infectious mononucleosis [11].
• Immunochemical studies of infectious mononucleosis. VIII. A glycoprotein from sheep erythrocytes with sialic acid-dependent receptor properties [12].
• Both oral and intravenous acyclovir administration for seven days in the early stages of infectious mononucleosis caused an inhibition of oropharyngeal Epstein-Barr virus (EBV) replication [13].

Biological context of Infectious Mononucleosis

• Down-regulation of pan-T-cell antigens, particularly CD7, in acute infectious mononucleosis [14].
• To further evaluate the antibody specificity of the RIA, the antibody titers of paired sera, pre- or early infection and postinfection, from five confirmed infectious mononucleosis patients were determined by RIA and IFA [15].
• These results suggest that patients with the fatal infectious mononucleosis phenotype of XLP may produce endogenous IFN-gamma [16].
• No cross-reactions were observed when paired sera from 22 patients with herpes simplex or varicella and single sera from 12 patients with suspected infectious mononucleosis were tested by the direct enzyme-linked immunosorbent assay [17].
• Sera from patients with acute infectious mononucleosis (IM), which develop EBV-specific killer T cells, did not induce ADCC [18].

Anatomical context of Infectious Mononucleosis

• In lymphoid tissues from patients with acute infectious mononucleosis (IM), interfollicular immunoblasts were shown to express LMP2A [19].
• The Epstein-Barr virus (EBV) has been associated with classic infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and B-cell lymphomas in primary and secondary immunodeficiency disease [20].
• Epstein Barr virus selective T cells in infectious mononucleosis are not restricted to HLA-A and B antigens [21].
• Colonies of EBNA-positive cells in soft agar from peripheral leukocytes of infectious mononucleosis patients [22].
• Clinical symptoms, immunoglobulin levels, immunoglobulin secreting cell numbers and mononuclear cell purine enzyme activities during the course of infectious mononucleosis [23].

Gene context of Infectious Mononucleosis

• Immunohistochemistry confirmed that PTLD tissues contain less IL-18 and Mig protein than tissues with infectious mononucleosis [24].
• Finally, serum CCL22 levels were significantly elevated in infectious mononucleosis [25].
• Expansion of a CD28-intermediate subset among CD8 T cells in patients with infectious mononucleosis [26].
• Interferon-alpha, IL-1 beta, and IL-6 levels were not significantly increased in any patient group but inferferon-gamma levels were significantly increased during the acute phase of infectious mononucleosis [27].
• The levels of IL-1 alpha were significantly higher than in controls both in patients with infectious mononucleosis and in those with chronic fatigue syndrome [27].

Analytical, diagnostic and therapeutic context of Infectious Mononucleosis

• A sensitive enzyme-linked immunosorbent assay was used to measure titers of IgG antibodies against bacterially synthesized Epstein-Barr virus nuclear antigen and early antigen in sera from 100 healthy North Americans, 40 North American patients with infectious mononucleosis, and 48 Asian patients with nasopharyngeal carcinoma [28].
• Thirty-one patients with clinical and laboratory diagnoses of infectious mononucleosis who had had symptoms for seven or fewer days were randomized for intravenous treatment with acyclovir (10 mg/kg) or placebo at 8-hr intervals for seven days in a double-blind trial [29].
• Latex test for serodiagnosis of infectious mononucleosis [30].
• The advantage of the ELISAs for seroepidemiologic studies on Epstein-Barr virus was demonstrated by sensitive detection of marginal immunoglobulin G antibody to the EBNA-1 domain in serum samples from patients with infectious mononucleosis [31].
• Comparative evaluation of two test methods (enzyme immunoassay and latex fixation) for the detection of heterophil antibodies in infectious mononucleosis [32].

References