The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Dlx2  -  distal-less homeobox 2

Rattus norvegicus

Synonyms: DLX-5, Homeobox protein DLX-2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Dlx2

  • In previous experiments, we showed that Sonic hedgehog treatment of forebrain neural explants results in the activation of Dlx-2 and the novel noncoding RNA (ncRNA), Evf-1 [1].
  • Evf-2 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner [1].
  • Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia [2].
  • To investigate the role of Dlx genes during development, we studied their cellular localization in primary cultures of embryonic basal telencephalon, and examined the changes in cellular phenotypes resulting from blockade of Dlx-2 expression [2].
  • We suggest that the Dlx-2 gene product regulates two interrelated aspects of neuronal differentiation: the exit from the mitotic cycle and the capability to grow MAP2-positive dendrites [2].

Biological context of Dlx2


Analytical, diagnostic and therapeutic context of Dlx2

  • To determine whether FORSE-1 has a labeling pattern similar to that of known transcription factors, the expression of BF-1 and Dlx-2 was examined by in situ hybridization on sections serial to those labeled with FORSE-1 [4].


  1. The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Feng, J., Bi, C., Clark, B.S., Mady, R., Shah, P., Kohtz, J.D. Genes Dev. (2006) [Pubmed]
  2. Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia. Ding, M., Robel, L., James, A.J., Eisenstat, D.D., Leckman, J.F., Rubenstein, J.L., Vaccarino, F.M. J. Mol. Neurosci. (1997) [Pubmed]
  3. Autoregulatory mechanism of Runx2 through the expression of transcription factors and bone matrix proteins in multipotential mesenchymal cell line, ROB-C26. Takahashi, T., Kato, S., Suzuki, N., Kawabata, N., Takagi, M. Journal of oral science. (2005) [Pubmed]
  4. Regionalization of the developing forebrain: a comparison of FORSE-1, Dlx-2, and BF-1. Tole, S., Patterson, P.H. J. Neurosci. (1995) [Pubmed]
WikiGenes - Universities