Gene Review:
Dlx5 - distal-less homeobox 5
Mus musculus
Synonyms:
AI385752, Homeobox protein DLX-5
- Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Acampora, D., Merlo, G.R., Paleari, L., Zerega, B., Postiglione, M.P., Mantero, S., Bober, E., Barbieri, O., Simeone, A., Levi, G. Development (1999)
- Dlx5 regulates chondrocyte differentiation at multiple stages. Bendall, A.J., Hu, G., Levi, G., Abate-Shen, C. Int. J. Dev. Biol. (2003)
- Dlx5 induces expression of COL1A1 promoter contained in a retrovirus vector. Tadić, T., Erceg, I., Stover, M.L., Rowe, D.W., Lichtler, A.C. Croat. Med. J. (2001)
- Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Horike, S., Cai, S., Miyano, M., Cheng, J.F., Kohwi-Shigematsu, T. Nat. Genet. (2005)
- The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Feng, J., Bi, C., Clark, B.S., Mady, R., Shah, P., Kohtz, J.D. Genes Dev. (2006)
- Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Riccomagno, M.M., Takada, S., Epstein, D.J. Genes Dev. (2005)
- Intergenic enhancers with distinct activities regulate Dlx gene expression in the mesenchyme of the branchial arches. Park, B.K., Sperber, S.M., Choudhury, A., Ghanem, N., Hatch, G.T., Sharpe, P.T., Thomas, B.L., Ekker, M. Dev. Biol. (2004)
- The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway. Merlo, G.R., Paleari, L., Mantero, S., Zerega, B., Adamska, M., Rinkwitz, S., Bober, E., Levi, G. Dev. Biol. (2002)
- Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Levi, G., Mantero, S., Barbieri, O., Cantatore, D., Paleari, L., Beverdam, A., Genova, F., Robert, B., Merlo, G.R. Mech. Dev. (2006)
- Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation. Zhou, Q.P., Le, T.N., Qiu, X., Spencer, V., de Melo, J., Du, G., Plews, M., Fonseca, M., Sun, J.M., Davie, J.R., Eisenstat, D.D. Nucleic Acids Res. (2004)
- A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. Zerucha, T., Stühmer, T., Hatch, G., Park, B.K., Long, Q., Yu, G., Gambarotta, A., Schultz, J.R., Rubenstein, J.L., Ekker, M. J. Neurosci. (2000)
- Defective neuronogenesis in the absence of Dlx5. Perera, M., Merlo, G.R., Verardo, S., Paleari, L., Corte, G., Levi, G. Mol. Cell. Neurosci. (2004)
- Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression. Stühmer, T., Anderson, S.A., Ekker, M., Rubenstein, J.L. Development (2002)
- BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. Lee, M.H., Kim, Y.J., Kim, H.J., Park, H.D., Kang, A.R., Kyung, H.M., Sung, J.H., Wozney, J.M., Kim, H.J., Ryoo, H.M. J. Biol. Chem. (2003)
- Methylation of the Mouse DIx5 and Osx Gene Promoters Regulates Cell Type-specific Gene Expression. Lee, J.Y., Lee, Y.M., Kim, M.J., Choi, J.Y., Park, E.K., Kim, S.Y., Lee, S.P., Yang, J.S., Kim, D.S. Mol. Cells (2006)
- MSX2 expression in the apical ectoderm ridge is regulated by an MSX2 and Dlx5 binding site. Pan, Z.Z., Kronenberg, M.S., Huang, D.Y., Sumoy, L., Rogina, B., Lichtler, A.C., Upholt, W.B. Biochem. Biophys. Res. Commun. (2002)
- BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. Shea, C.M., Edgar, C.M., Einhorn, T.A., Gerstenfeld, L.C. J. Cell. Biochem. (2003)
- Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Liu, J.K., Ghattas, I., Liu, S., Chen, S., Rubenstein, J.L. Dev. Dyn. (1997)
- Deletion of the endothelin-A receptor gene within the developing mandible. Ruest, L.B., Kedzierski, R., Yanagisawa, M., Clouthier, D.E. Cell Tissue Res. (2005)
- BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Lee, M.H., Kwon, T.G., Park, H.S., Wozney, J.M., Ryoo, H.M. Biochem. Biophys. Res. Commun. (2003)
- The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse. Levi, G., Puche, A.C., Mantero, S., Barbieri, O., Trombino, S., Paleari, L., Egeo, A., Merlo, G.R. Mol. Cell. Neurosci. (2003)
- Expression of murine Lhx5 suggests a role in specifying the forebrain. Sheng, H.Z., Bertuzzi, S., Chiang, C., Shawlot, W., Taira, M., Dawid, I., Westphal, H. Dev. Dyn. (1997)
- Dlx gene expression during chick inner ear development. Brown, S.T., Wang, J., Groves, A.K. J. Comp. Neurol. (2005)
- Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Lin, Z., Cantos, R., Patente, M., Wu, D.K. Development (2005)
- Dlx5, the mouse homologue of the human-imprinted DLX5 gene, is biallelically expressed in the mouse brain. Kimura, M.I., Kazuki, Y., Kashiwagi, A., Kai, Y., Abe, S., Barbieri, O., Levi, G., Oshimura, M. J. Hum. Genet. (2004)