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Gene Review

Sult4a1  -  sulfotransferase family 4A, member 1

Mus musculus

Synonyms: 2400007A17Rik, AI853543, BR-STL-1, Brain sulfotransferase-like protein, NST, ...
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High impact information on Sult4a1

  • Cured animals contained tumor-specific T cells of both host and donor origin, but immunodeficient hosts could not be cured by NST, DLI, and vaccine administration [1].
  • Thus, transfer of allogeneic donor T cells may help break functional tolerance of a host immune system to a solid tumor, thereby providing a rationale for the generation of mixed hematopoietic chimerism by NST prior to tumor cell vaccination [1].
  • Here we report a novel cooperation between host and donor T cells in the response to a tumor cell vaccine given after a nonmyeloablative allogeneic stem cell transplantation (NST) protocol that achieves stable mixed bone marrow chimerism [1].
  • Treatment of animals with NST, posttransplantation donor lymphocyte infusions (DLIs), and a vaccine, comprising irradiated autologous tumor cells mixed with a granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing bystander line, results in potent and specific antitumor immunity [1].
  • In desert adapted species, non-shivering thermogenesis NST-capacity (the ratio between the maximal VO2 response to noradrenaline injection and RMR, measured 1 degree C below the lower critical point) increased, as due to long scotophase acclimation [2].

Biological context of Sult4a1

  • These data suggest that perioperative NST may contribute to prolonged skin graft survival in burned recipients, provided that the mice are sufficiently immunosuppressed [3].

Analytical, diagnostic and therapeutic context of Sult4a1

  • The focus of the present study was to determine the effect of pretransplant and perioperative donor-specific (DST) or nonspecific (NST) blood transfusion on skin allograft survival in thermally injured mice [3].
  • The relative NST increase after treatment was always greater than the relative ST increase either at sites where before treatment NST was greater than ST or at sites where NST was shorter than ST [4].


  1. Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras. Luznik, L., Slansky, J.E., Jalla, S., Borrello, I., Levitsky, H.I., Pardoll, D.M., Fuchs, E.J. Blood (2003) [Pubmed]
  2. Thermoregulatory responses of mesic and xeric rodent species to photoperiod manipulations. Haim, A., Shabtay, A., Arad, Z. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (1998) [Pubmed]
  3. Transfusion-induced sensitization to skin allografts in burned mice. Shelby, J., Krob, M.J. The Journal of trauma. (1986) [Pubmed]
  4. Effects of acetoxycycloheximide and anisomycin on approach and escape responses to hypothalamic stimulation. Ungerer, A., Back, M., Schmitt, P. Physiol. Behav. (1985) [Pubmed]
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