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Gene Review

Clic4  -  chloride intracellular channel 4...

Mus musculus

Synonyms: Chloride intracellular channel protein 4, D0Jmb3, TU-74, mc3s5, mc3s5/mtCLIC, ...
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High impact information on Clic4


Biological context of Clic4


Anatomical context of Clic4


Associations of Clic4 with chemical compounds

  • Mitochondrial chloride intracellular channel (mtCLIC), a member of a recently discovered and expanding family of chloride intracellular channels, is up-regulated in mtDNA-depleted and rho0 cells [4].

Analytical, diagnostic and therapeutic context of Clic4


  1. mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. Fernández-Salas, E., Suh, K.S., Speransky, V.V., Bowers, W.L., Levy, J.M., Adams, T., Pathak, K.R., Edwards, L.E., Hayes, D.D., Cheng, C., Steven, A.C., Weinberg, W.C., Yuspa, S.H. Mol. Cell. Biol. (2002) [Pubmed]
  2. The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis. Suh, K.S., Mutoh, M., Nagashima, K., Fernandez-Salas, E., Edwards, L.E., Hayes, D.D., Crutchley, J.M., Marin, K.G., Dumont, R.A., Levy, J.M., Cheng, C., Garfield, S., Yuspa, S.H. J. Biol. Chem. (2004) [Pubmed]
  3. p53 and tumor necrosis factor alpha regulate the expression of a mitochondrial chloride channel protein. Fernández-Salas, E., Sagar, M., Cheng, C., Yuspa, S.H., Weinberg, W.C. J. Biol. Chem. (1999) [Pubmed]
  4. mtCLIC is up-regulated and maintains a mitochondrial membrane potential in mtDNA-depleted L929 cells. Arnould, T., Mercy, L., Houbion, A., Vankoningsloo, S., Renard, P., Pascal, T., Ninane, N., Demazy, C., Raes, M. FASEB J. (2003) [Pubmed]
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